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Comprehensive geriatric assessment in newly diagnosed older myeloma patients: a multicentre, prospective, non-interventional study

Authors :
Fengyan Jin
Chenglu Yuan
Dehui Zou
Li Bao
Hua Yan
Xi-Nan Cen
Chunyan Sun
Da Gao
Jianda Hu
Guang-Xun Gao
Daobin Zhou
Rong Fu
Jian Li
Lu Zhang
Weiwei Sui
Yuan Yao
Aijun Liao
Xiao-Xia Chu
Liang-Ming Ma
Wei Wang
Jianxia He
Lijuan Chen
Jin-Qiao Zhang
Hui Liu
L. Wang
Source :
Age and Ageing. 51
Publication Year :
2021
Publisher :
Oxford University Press (OUP), 2021.

Abstract

Background Multiple myeloma is a disease of the older people, whose prognoses are highly heterogeneous. The International Myeloma Working Group (IMWG) proposed a geriatric assessment (GA) based on age, functional status and comorbidities to discriminate between fit and frail patients. Given the multidimensional nature of frailty and the relatively recent exploration of frailty in the field of MM, reaching a consensus on the measurement of frailty in MM patients remains challenging. Objective We sought to assess the feasibility of performing a comprehensive GA (CGA) in older MM patients in a real-world and multicentre setting and to evaluate their baseline CGA profiles. Results We studied 349 older patients with newly diagnosed MM (age range, 65–86 years). Our results showed that a CGA is feasible for older MM patients. Using the IMWG-GA criteria, we identified significantly more frail patients in our cohort comparing to in the IMWG cohort (43% vs 30%, P = 0.002). In the IMWG-GA ‘fit’ group, risk of malnutrition, depression and cognitive impairment remains. The median follow-up time was 26 months (range 1–38). The median overall survival (OS) was 34.7 months, and the estimated 3-year OS rate was 50%. A high MNA-SF score (MNA-SF ≥ 12), low GDS score (GDS ≤ 5) and high CCI score (CCI ≥ 2) can be used to predict the OS of older patients with newly diagnosed MM. This study is registered at www.clinicaltrials.gov (NCT03122327). Conclusions Our study justifies the need for a CGA in older patients with newly diagnosed MM.

Details

ISSN :
14682834 and 00020729
Volume :
51
Database :
OpenAIRE
Journal :
Age and Ageing
Accession number :
edsair.doi.dedup.....b4fe32c4d27999b51c26e2e73a746c41