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Treatment of Hyperlipidemia With a Modified Low Density Lipoprotein Apheresis System With Dextran Sulfate

Treatment of Hyperlipidemia With a Modified Low Density Lipoprotein Apheresis System With Dextran Sulfate

Authors :
Chang-Ying Xing
Yi-Hua Zhao
Dai Xi
Qi-Jun Sun
Yuan-Guo Zou
Source :
Therapeutic Apheresis and Dialysis. 11:249-254
Publication Year :
2007
Publisher :
Wiley, 2007.

Abstract

Many low density lipoprotein (LDL) apheresis systems have been applied to patients with hyperlipidemia, but these systems usually work on the basis of complicated equipment and the cost of treatment is expensive. In order to achieve effective treatment of hyperlipidemia at a lower cost, we developed a new LDL apheresis system with dextran sulfate (LAS-DS). In this study, 50 patients with hyperlipidemia were treated 120 times with the new LAS-DS. In each treatment, 600 ± 100 mL of plasma (equal to approximately 25% of the total plasma of patients) was collected by apheresis, and DS solution and calcium chloride solution were added into the collected plasma as LDL absorber and catalyzer, respectively. DS selectively binds LDL cholesterol (LDL-C) under the catalysis of calcium ion and the LDL-C-DS complex is removed by centrifugation. The treated plasma was transfused back into the patients and the excessive calcium in the plasma was removed by the cation exchange column integrated in the transfusion set. After treatment with our new system, the acute mean LDL-C reduction was 97% in the apheresis plasma of hyperlipidemia patients. The corresponding reduction was 55.2% and 69.4% for total cholesterol and total triglyceride. There were insignificant reductions of high density lipoprotein cholesterol (HDL-C) and albumin. The new LDL apheresis system with DS that we developed is very simple to operate without relying on complicated equipment, and it can achieve significant clinical results at a much lower cost compared with existing systems. Based on this study we think the new system can provide a safe, effective and much cheaper means for the treatment of hyperlipidemia patients.

Details

ISSN :
17449987 and 17449979
Volume :
11
Database :
OpenAIRE
Journal :
Therapeutic Apheresis and Dialysis
Accession number :
edsair.doi.dedup.....b4fe5cf3cca4cbe69ec114beae91eb84
Full Text :
https://doi.org/10.1111/j.1744-9987.2007.00487.x