Back to Search
Start Over
Effects of intravenous dextrose on preventing postoperative nausea and vomiting: A systematic review and meta-analysis with trial sequential analysis
- Source :
- PLoS ONE, PLoS ONE, Vol 15, Iss 4, p e0231958 (2020)
- Publication Year :
- 2020
- Publisher :
- Public Library of Science, 2020.
-
Abstract
- BackgroundIt is reported that postoperative nausea and vomiting, common general anesthesia complications, may be prevented by perioperative intravenous dextrose administration, but with controversial clinical effectiveness.ObjectiveTo evaluate perioperative intravenous dextrose for preventing postoperative nausea and vomiting through a systematic review and meta-analysis of randomized controlled trials with trial sequential analysis.Data sourcesMEDLINE, the Cochrane Central Register of Controlled Trials, Embase, Web of Science, clinicaltrials.gov, and the University Hospital Medical Information Network Clinical Trials Registry were searched from inception until 22 June 2019.Eligibility criteriaTrials investigating intravenous dextrose effects vs. placebos on postoperative nausea and vomiting in patients who underwent general anesthesia.ResultsEleven trials (1,250 patients) were included. All participants were ASA1-2. The nine trials included laparoscopic surgeries, and 92.2% of the participants were women. The timing of dextrose infusion was before, during, and after surgery in three, five, and three trials, respectively. Our results revealed intravenous dextrose administration significantly reduced postoperative nausea, but not vomiting, during early and late postoperative periods (risk ratio [95% confidence interval], early nausea: 0.76 [0.59-0.99], late nausea: 0.65 [0.48-0.89]; early vomiting: 1.00 [0.81-1.25], late vomiting: 0.96 [0.43-2.16]). Evidence quality was downgraded to low because the trial sequential analysis indicated more trials are needed for firm conclusions.ConclusionsCompared with placebos, perioperative intravenous dextrose administration may decrease postoperative nausea but not vomiting.Trial registrationUniversity Hospital Medical Information Network Clinical Trials Registry (registration number: UMIN000030901).
- Subjects :
- Blood Glucose
Databases, Factual
Physiology
Pathology and Laboratory Medicine
law.invention
0302 clinical medicine
Mathematical and Statistical Techniques
Randomized controlled trial
030202 anesthesiology
law
Medicine and Health Sciences
030212 general & internal medicine
Multidisciplinary
Organic Compounds
Anesthesia complication
Monosaccharides
Statistics
Gynecologic Surgery
Nausea
Metaanalysis
Blood Sugar
Body Fluids
Chemistry
Blood
Anesthesia
Physical Sciences
Vomiting
Medicine
Administration, Intravenous
medicine.symptom
Anatomy
Research Article
Risk
Science
Carbohydrates
Surgical and Invasive Medical Procedures
Research and Analysis Methods
03 medical and health sciences
Signs and Symptoms
Diagnostic Medicine
medicine
Humans
Statistical Methods
business.industry
Organic Chemistry
Chemical Compounds
Biology and Life Sciences
Perioperative
Clinical trial
Glucose
Relative risk
Postoperative Nausea and Vomiting
Laparoscopy
business
Physiological Processes
Postoperative nausea and vomiting
Mathematics
Subjects
Details
- Language :
- English
- ISSN :
- 19326203
- Volume :
- 15
- Issue :
- 4
- Database :
- OpenAIRE
- Journal :
- PLoS ONE
- Accession number :
- edsair.doi.dedup.....b54486a0a66e1f358ec6293213221615