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Hematogenous metastasis of ovarian cancer: Rethinking mode of spread
- Publication Year :
- 2014
-
Abstract
- SummaryOvarian cancer has a clear predilection for metastasis to the omentum, but the underlying mechanisms involved in ovarian cancer spread are not well understood. Here, we used a parabiosis model that demonstrates preferential hematogenous metastasis of ovarian cancer to the omentum. Our studies revealed that the ErbB3-neuregulin 1 (NRG1) axis is a dominant pathway responsible for hematogenous omental metastasis. Elevated levels of ErbB3 in ovarian cancer cells and NRG1 in the omentum allowed for tumor cell localization and growth in the omentum. Depletion of ErbB3 in ovarian cancer impaired omental metastasis. Our results highlight hematogenous metastasis as an important mode of ovarian cancer metastasis. These findings have implications for designing alternative strategies aimed at preventing and treating ovarian cancer metastasis.
- Subjects :
- Cancer Research
Time Factors
endocrine system diseases
Receptor, ErbB-3
Carcinoma, Ovarian Epithelial
Metastasis
Mice
0302 clinical medicine
Cell Movement
ERBB3
Neoplasms, Glandular and Epithelial
Peritoneal Neoplasms
Ovarian Neoplasms
0303 health sciences
Neoplastic Cells, Circulating
female genital diseases and pregnancy complications
3. Good health
Oncology
030220 oncology & carcinogenesis
Ovarian cancer cells
Female
RNA Interference
Omentum
Signal Transduction
endocrine system
Parabiosis
Neuregulin-1
Mice, Nude
Biology
Transfection
Article
03 medical and health sciences
Cell Line, Tumor
Carcinoma
medicine
Animals
Humans
Neoplasm Invasiveness
030304 developmental biology
Cell Proliferation
Hematogenous metastasis
Cell Biology
medicine.disease
Xenograft Model Antitumor Assays
body regions
Mice, Inbred C57BL
Omental metastasis
Immunology
Cancer research
Ovarian cancer
Subjects
Details
- Language :
- English
- Database :
- OpenAIRE
- Accession number :
- edsair.doi.dedup.....b551d17f3aeb1d8b390774b7088f5b5a