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Combined C4d and CD3 immunostaining predicts immunoglobulin (Ig)A nephropathy progression
- Source :
- Clinical and Experimental Immunology, 179(2), 354-361. Wiley
- Publication Year :
- 2015
-
Abstract
- Summary A number of molecules have been shown recently to be involved in the pathogenesis and progression of immunoglobulin (Ig)A nephropathy (IgAN). Among these, we have selected C4d (complement lectin pathway involvement), CD3 (T cell marker, traducing interstitial inflammation), transglutaminase 2 (TGase-2, involved in tissue fibrosis development) and p-extracelluar-regulated kinase (ERK)1/2 (protein kinase intracellular signaling molecule) to perform a panel of immunohistological biomarkers and assess its predictive value for disease progression. Immunohistochemical staining of these biomarkers was performed in paraffin sections from 74 renal biopsy cases with the clinical diagnosis of IgAN. Association between score analysis of these parameters and disease course was assessed through univariate and multivariate analysis, including baseline clinical and histological data. Univariate analysis showed that glomerular C4d, tubulointerstitial TGase2 and CD3 scores were associated with baseline proteinuria and disease progression. Multivariate analysis showed that only baseline estimated glomerular filtration rate (eGFR), C4d and CD3 were associated independently with progressive kidney disease (decline of at least 50% in the eGFR or progression to end-stage renal disease (ESRD) during the follow-up period). Establishing an accurate prediction model for IgAN progression is still a matter of research in clinical nephrology. The complement system, particularly lectin pathway activation, and T cell activation, have been shown previously to be potential modifiers of the disease course. Here we show that the combination of two histological biomarkers (C4d and CD3) can be a powerful predictor of IgAN progression and a potential useful tool for the clinical approach of this disease.
- Subjects :
- Male
IGA NEPHROPATHY
Pathology
CD3 Complex
T-Lymphocytes
Lymphocyte Activation
urologic and male genital diseases
Pathogenesis
Immunology and Allergy
complement
TISSUE TRANSGLUTAMINASE
DEPOSITION
Mitogen-Activated Protein Kinase 1
Univariate analysis
Mitogen-Activated Protein Kinase 3
medicine.diagnostic_test
autoimmunity
Complement C4
Glomerulonephritis
Middle Aged
Immunohistochemistry
Lectin pathway
Disease Progression
KINASE PATHWAY
Female
Renal biopsy
COMPLEMENT ACTIVATION
Glomerular Filtration Rate
Adult
medicine.medical_specialty
OXFORD CLASSIFICATION
Adolescent
MAP Kinase Signaling System
Immunology
T cells
Renal function
Biology
Models, Biological
Nephropathy
LECTIN PATHWAY
GLOMERULONEPHRITIS
MESANGIAL CELLS
medicine
Humans
Aged
Retrospective Studies
Glomerulonephritis, IGA
Original Articles
medicine.disease
RENAL-DISEASE
Kidney Failure, Chronic
Follow-Up Studies
Kidney disease
Subjects
Details
- Language :
- English
- ISSN :
- 00099104
- Volume :
- 179
- Issue :
- 2
- Database :
- OpenAIRE
- Journal :
- Clinical and Experimental Immunology
- Accession number :
- edsair.doi.dedup.....b5530e88b8efaf999b3e1bfcd5761f00
- Full Text :
- https://doi.org/10.1111/cei.12461