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Molecular pathways and molecular imaging in breast cancer: An update
- Source :
- Nuclear Medicine and Biology. 40:581-591
- Publication Year :
- 2013
- Publisher :
- Elsevier BV, 2013.
-
Abstract
- Breast cancer is a heterogenic cancer being characterized by a variability of somatic mutations and in particular by different receptor expressions, such as estrogen, progesterone and human epidermal receptor. These phenotype characteristics play a crucial role in determining tumour response to various chemotherapies and other treatments and in the development of resistance to therapies. Positron emission tomography (PET) as a nuclear medicine technique, has recently demonstrated the advantages in determining the severity of disease and in evaluating the efficacy of treatments in a variety of neoplasm, including breast cancer. Because this procedure is able to pinpoint molecular activity within the body, it offers the potential to identify disease in its earliest stages as well as a patient's immediate response to therapeutic interventions in a non-invasive way. In this paper we performed an extended view about the correlation between molecular factors of breast cancer and PET tracers; in particular, we focalized our attention on their possible advantages in terms of 1) early detection of primary or recurrent cancer; 2) as a guide for target therapies and 3) for the evaluation of response to specific and now-available molecular treatments.
- Subjects :
- Oncology
Cancer Research
medicine.medical_specialty
Pathology
medicine.drug_class
Apoptosis
Breast Neoplasms
Disease
Breast cancer
Internal medicine
medicine
Humans
Neoplasm
Radiology, Nuclear Medicine and imaging
Radioactive Tracers
medicine.diagnostic_test
business.industry
Cancer
DNA
medicine.disease
Phenotype
Molecular Imaging
ErbB Receptors
Positron emission tomography
Estrogen
Molecular Medicine
Molecular imaging
business
Subjects
Details
- ISSN :
- 09698051
- Volume :
- 40
- Database :
- OpenAIRE
- Journal :
- Nuclear Medicine and Biology
- Accession number :
- edsair.doi.dedup.....b55ac81e05f0338db10cde7384eeceee
- Full Text :
- https://doi.org/10.1016/j.nucmedbio.2013.03.002