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Effect of paracetamol use on the modification of the development of asthma by reactive oxygen species genes
- Source :
- Annals of Allergy, Asthma & Immunology. 110:364-369.e1
- Publication Year :
- 2013
- Publisher :
- Elsevier BV, 2013.
-
Abstract
- Background Recent studies have identified an increase in the prevalence of asthma associated with paracetamol use. Objective To identify the relationship among asthma, biomarkers, genes, and paracetamol use in preschool children. Methods We undertook a population-based, cross-sectional survey of 933 preschool children. Asthma status was classified according to medical history and asthmatic symptoms. History of paracetamol use in infancy was recorded. Impulse oscillometry, blood tests for eosinophils and total IgE, and genotyping of NAT2 , Nrf2 , and GSTP1 polymorphisms by TaqMan assay were conducted. Result Paracetamol use in infancy was associated with an increased risk of treatment for asthma within the previous 12 months. Paracetamol use together with a family history of asthma increased the risk of asthma diagnosis ever, current asthma, and treatment for asthma within the previous 12 months. Gene polymorphisms in NAT2 (rs4271002), Nrf2 (rd6726395), and GSTP1 (rd1695) increased the risk of treatment for asthma within the last 12 months. Eosinophils were significantly elevated in the group with paracetamol use and a family history of asthma; however, the serum total IgE level and IOS did not show any significant difference. Conclusion Paracetamol use in infancy was significantly associated with increased risk of asthma. The association is more significant in genetically susceptible children, related to antioxidant genes, and the effect may be mediated by eosinophilic inflammation.
- Subjects :
- Male
Risk
Pulmonary and Respiratory Medicine
Arylamine N-Acetyltransferase
NF-E2-Related Factor 2
Cross-sectional study
Immunology
Immunoglobulin E
Leukocyte Count
GSTP1
Oscillometry
medicine
Humans
Immunology and Allergy
Genetic Predisposition to Disease
Medical history
Family history
Child
Genotyping
Acetaminophen
Asthma
Polymorphism, Genetic
biology
business.industry
Analgesics, Non-Narcotic
medicine.disease
respiratory tract diseases
Eosinophils
Cross-Sectional Studies
Glutathione S-Transferase pi
Child, Preschool
biology.protein
Female
Reactive Oxygen Species
business
medicine.drug
Subjects
Details
- ISSN :
- 10811206
- Volume :
- 110
- Database :
- OpenAIRE
- Journal :
- Annals of Allergy, Asthma & Immunology
- Accession number :
- edsair.doi.dedup.....b55ae3d525caff9b407d52b7f104ebc8