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Maraviroc Pharmacokinetics in HIV-1-Infected Pregnant Women
- Source :
- Clinical Infectious Diseases, 61, 10, pp. 1582-9, Clinical Infectious Diseases, 61, 1582-9, Clinical Infectious Diseases, 61(10), 1582-1589. Oxford University Press
- Publication Year :
- 2015
-
Abstract
- Contains fulltext : 152455.pdf (Publisher’s version ) (Closed access) OBJECTIVE: To describe the pharmacokinetics of maraviroc in human immunodeficiency virus (HIV)-infected women during pregnancy and post partum. METHODS: HIV-infected pregnant women receiving maraviroc as part of clinical care had intensive steady-state 12-hour pharmacokinetic profiles performed during the third trimester and >/=2 weeks after delivery. Cord blood samples and matching maternal blood samples were taken at delivery. The data were collected in 2 studies: P1026 (United States) and PANNA (Europe). Pharmacokinetic parameters were calculated. RESULTS: Eighteen women were included in the analysis. Most women (12; 67%) received 150 mg of maraviroc twice daily with a protease inhibitor, 2 (11%) received 300 mg twice daily without a protease inhibitor, and 4 (22%) had an alternative regimen. The geometric mean ratios for third-trimester versus postpartum maraviroc were 0.72 (90% confidence interval, .60-.88) for the area under the curve over a dosing interval (AUCtau) and 0.70 (0.58-0.85) for the maximum maraviroc concentration. Only 1 patient showed a trough concentration (Ctrough) below the suggested target of 50 ng/mL, both during pregnancy and post partum. The median ratio of maraviroc cord blood to maternal blood was 0.33 (range, 0.03-0.56). The viral load close to delivery was
- Subjects :
- Adult
Microbiology (medical)
medicine.medical_specialty
Anti-HIV Agents
lnfectious Diseases and Global Health Radboud Institute for Molecular Life Sciences [Radboudumc 4]
HIV Infections
Maraviroc
Young Adult
chemistry.chemical_compound
Pharmacokinetics
SDG 3 - Good Health and Well-being
Cyclohexanes
Pregnancy
medicine
Humans
Trough Concentration
Pregnancy Complications, Infectious
Obstetrics
business.industry
Area under the curve
Triazoles
medicine.disease
United States
Confidence interval
Surgery
Europe
Regimen
Infectious Diseases
lnfectious Diseases and Global Health Radboud Institute for Health Sciences [Radboudumc 4]
chemistry
HIV/AIDS
Female
business
Viral load
Blood Chemical Analysis
Subjects
Details
- ISSN :
- 10584838
- Volume :
- 61
- Issue :
- 10
- Database :
- OpenAIRE
- Journal :
- Clinical Infectious Diseases
- Accession number :
- edsair.doi.dedup.....b59589dabd1aa1888c3e7410180226e9