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Plasmonic Interferometers as TREM2 Sensors for Alzheimer’s Disease

Authors :
Dongfang Li
Domenico Pacifici
Dingdong Li
Rachel Odessey
Source :
Biosensors, Volume 11, Issue 7, Biosensors, Vol 11, Iss 217, p 217 (2021)
Publication Year :
2021
Publisher :
MDPI, 2021.

Abstract

We report an effective surface immobilization protocol for capture of Triggering Receptor Expressed on Myeloid Cells 2 (TREM2), a receptor whose elevated concentration in cerebrospinal fluid has recently been associated with Alzheimer’s disease (AD). We employ the proposed surface functionalization scheme to design, fabricate, and assess a biochemical sensing platform based on plasmonic interferometry that is able to detect physiological concentrations of TREM2 in solution. These findings open up opportunities for label-free biosensing of TREM2 in its soluble form in various bodily fluids as an early indicator of the onset of clinical dementia in AD. We also show that plasmonic interferometry can be a powerful tool to monitor and optimize surface immobilization schemes, which could be applied to develop other relevant antibody tests.

Details

Language :
English
ISSN :
20796374
Volume :
11
Issue :
7
Database :
OpenAIRE
Journal :
Biosensors
Accession number :
edsair.doi.dedup.....b5a37bc0eca4d8555e97077864a0657b