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Plasmonic Interferometers as TREM2 Sensors for Alzheimer’s Disease
- Source :
- Biosensors, Volume 11, Issue 7, Biosensors, Vol 11, Iss 217, p 217 (2021)
- Publication Year :
- 2021
- Publisher :
- MDPI, 2021.
-
Abstract
- We report an effective surface immobilization protocol for capture of Triggering Receptor Expressed on Myeloid Cells 2 (TREM2), a receptor whose elevated concentration in cerebrospinal fluid has recently been associated with Alzheimer’s disease (AD). We employ the proposed surface functionalization scheme to design, fabricate, and assess a biochemical sensing platform based on plasmonic interferometry that is able to detect physiological concentrations of TREM2 in solution. These findings open up opportunities for label-free biosensing of TREM2 in its soluble form in various bodily fluids as an early indicator of the onset of clinical dementia in AD. We also show that plasmonic interferometry can be a powerful tool to monitor and optimize surface immobilization schemes, which could be applied to develop other relevant antibody tests.
- Subjects :
- Materials science
Clinical Biochemistry
Nanotechnology
Article
TREM2 sensors
03 medical and health sciences
0302 clinical medicine
plasmonic interferometry
Alzheimer Disease
Astronomical interferometer
Humans
Receptors, Immunologic
Plasmon
030304 developmental biology
surface functionalization
0303 health sciences
Membrane Glycoproteins
optical biosensor
TREM2
Brain
General Medicine
Interferometry
Myeloid cells
Surface modification
Effective surface
Biosensor
Alzheimer’s disease
TP248.13-248.65
030217 neurology & neurosurgery
Biotechnology
Subjects
Details
- Language :
- English
- ISSN :
- 20796374
- Volume :
- 11
- Issue :
- 7
- Database :
- OpenAIRE
- Journal :
- Biosensors
- Accession number :
- edsair.doi.dedup.....b5a37bc0eca4d8555e97077864a0657b