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Single Nucleotide Polymorphism rs6942067 Is a Risk Factor in Young and in Non-Smoking Patients with HPV Negative Head and Neck Squamous Cell Carcinoma
- Source :
- Cancers, Volume 12, Issue 1, Cancers, Vol 12, Iss 1, p 55 (2019)
- Publication Year :
- 2019
- Publisher :
- Multidisciplinary Digital Publishing Institute, 2019.
-
Abstract
- Genetic factors behind the increasing incidence of human papillomavirus (HPV) negative head and neck squamous cell carcinoma (HNSCC) in young non-smokers are suspected, but have not been identified. Recently, rs6942067, a single nucleotide polymorphism (SNP) located upstream of the DCBLD1 gene, was found associated with non-smoking lung adenocarcinoma. To validate if this SNP is also implicated in HNSCC, participants of The Cancer Genome Atlas HNSCC cohort were investigated for rs6942067 status, associated DCBLD1 expression, and clinical characteristics. Occurrence of the rs6942067 GG genotype is significantly higher in young and in HPV negative non-smoking HNSCC than in other HNSCC. Additionally, rs6942067 GG is associated with higher DCBLD1 expression in HNSCC and patients with high DCBLD1 expression have a worse overall survival at three years, both in univariate and multivariate analysis. Furthermore, high DCBLD1 expression is associated with activation of the integrin signaling pathway and its phosphorylation with EGFR and MET. Collectively, these findings suggest that DCBLD1 plays a critical role in HNSCC and demonstrate an association between rs6942067 and clinical characteristics of young age and HPV negative non-smoking status in HNSCC patients.
- Subjects :
- 0301 basic medicine
Oncology
Cancer Research
medicine.medical_specialty
Single-nucleotide polymorphism
head and neck squamous cell carcinoma
lcsh:RC254-282
tobacco
Article
DCBLD1
03 medical and health sciences
0302 clinical medicine
stomatognathic system
Internal medicine
Genotype
medicine
otorhinolaryngologic diseases
SNP
cancer susceptibility genes
rs6942067
human papillomavirus
Gene
neoplasms
Lung
business.industry
medicine.disease
lcsh:Neoplasms. Tumors. Oncology. Including cancer and carcinogens
Head and neck squamous-cell carcinoma
stomatognathic diseases
030104 developmental biology
medicine.anatomical_structure
030220 oncology & carcinogenesis
Cohort
Adenocarcinoma
business
Subjects
Details
- Language :
- English
- ISSN :
- 20726694
- Database :
- OpenAIRE
- Journal :
- Cancers
- Accession number :
- edsair.doi.dedup.....b5a7338d25c0589ad696d90ec0b27898
- Full Text :
- https://doi.org/10.3390/cancers12010055