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Cytokines and growth factors in the developing intestine and during necrotizing enterocolitis
- Source :
- Seminars in Perinatology. 41:52-60
- Publication Year :
- 2017
- Publisher :
- Elsevier BV, 2017.
-
Abstract
- Cytokines and growth factors play diverse roles in the uninflamed fetal/neonatal intestinal mucosa and in the development of inflammatory bowel injury during necrotizing enterocolitis (NEC). During gestational development and the early neonatal period, the fetal/premature intestine is exposed to high levels of many "inflammatory" cytokines and growth factors, first via swallowed amniotic fluid in utero and then, after birth, in colostrum and mother's milk. This article reviews the dual, seemingly counter-intuitive roles of cytokines, where these agents play a "trophic" role and promote maturation of the uninflamed mucosa, but can also cause inflammation and promote intestinal injury during NEC.
- Subjects :
- 0301 basic medicine
Amniotic fluid
Heparin-binding EGF-like growth factor
Inflammation
Infant, Premature, Diseases
Article
03 medical and health sciences
0302 clinical medicine
Intestinal mucosa
Enterocolitis, Necrotizing
030225 pediatrics
medicine
Humans
Intestinal Mucosa
Infant Nutritional Physiological Phenomena
Enterocolitis
Fetus
business.industry
Infant, Newborn
Gene Expression Regulation, Developmental
Obstetrics and Gynecology
medicine.disease
Immunity, Innate
030104 developmental biology
Infant, Extremely Low Birth Weight
Infant, Extremely Premature
Pediatrics, Perinatology and Child Health
Necrotizing enterocolitis
Immunology
Cytokines
Colostrum
Disease Susceptibility
medicine.symptom
business
Heparin-binding EGF-like Growth Factor
Subjects
Details
- ISSN :
- 01460005
- Volume :
- 41
- Database :
- OpenAIRE
- Journal :
- Seminars in Perinatology
- Accession number :
- edsair.doi.dedup.....b5abdaafe246290657730051e9b5ec3b