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Oroxylum Indicum ameliorates chemotherapy induced cognitive impairment
- Source :
- PLoS ONE, PLoS ONE, Vol 16, Iss 6, p e0252522 (2021)
- Publication Year :
- 2021
- Publisher :
- Public Library of Science (PLoS), 2021.
-
Abstract
- While chemotherapy is the most effective therapeutic approach for treating a variety of cancer patients, commonly used chemotherapeutic agents, often induce several adverse effects. Escalating evidence indicates that chemotherapeutics, particularly doxorubicin (DOX) and cyclophosphamide (CPS), induce cognitive impairment associated with central nervous system toxicity. This study was performed to determine neuroprotective effects of Oroxylum indicum extract (OIE) in regard to preventing chemotherapy induced cognitive impairment (CICI) occurring after 4 cycles of DOX (2mg/kg) and CPS (50mg/kg) combination chemotherapy in male C57BL/6J mice. OIE significantly prevented the chemotherapy impaired short-term cognitive performance, exploratory behavior associated with cognitive performance, cognitive performance, and spatial learning and memory in the Y-maze, Open-Field, Novel Object Recognition, and Morris Water Maze tests, respectively. These data suggest that OIE protects from the CICI. OIE decreased the reactive oxygen species and lipid peroxide generated by the chemotherapy treatment in the brain, while also blocking the chemotherapy-induced glutathione depletion. These results establish that OIE exhibits potent antioxidant activity in chemotherapy treated mice. Notably, OIE significantly increased the Complex-I and Complex-IV activities in the brain, indicating that OIE enhances mitochondrial function in the brain. In silico analysis of the major active chemical constituents (Oroxylin A, Baicalein and Chrysin) of OIE indicated that OIE has a favorable absorption, distribution, metabolism and excretion (ADME) profile. Taken together, our results are consistent with the conclusion that OIE prevents CICI by counteracting oxidative stress and perhaps by improving mitochondrial function.
- Subjects :
- Male
0301 basic medicine
Cancer Treatment
Social Sciences
Morris water navigation task
Pharmacology
medicine.disease_cause
Biochemistry
Mice
chemistry.chemical_compound
0302 clinical medicine
Medicine and Health Sciences
Psychology
Medicine
Chrysin
Energy-Producing Organelles
Cognitive Impairment
Multidisciplinary
Animal Behavior
Lipid peroxide
Pharmaceutics
Cognitive Neurology
Brain
Combination chemotherapy
Glutathione
Lipids
Mitochondria
Neuroprotective Agents
Oncology
Neurology
Cellular Structures and Organelles
Oxidation-Reduction
Research Article
medicine.drug
Science
Cognitive Neuroscience
Antineoplastic Agents
Bioenergetics
Neuroprotection
03 medical and health sciences
Drug Therapy
Chemotherapy-Related Cognitive Impairment
Chemotherapy
Animals
Cognitive Dysfunction
Doxorubicin
Behavior
Plant Extracts
business.industry
Biology and Life Sciences
Cell Biology
Mice, Inbred C57BL
Oxidative Stress
030104 developmental biology
chemistry
Cognitive Science
Oroxylin A
Lipid Peroxidation
Peptides
business
Zoology
030217 neurology & neurosurgery
Oxidative stress
Neuroscience
Subjects
Details
- ISSN :
- 19326203
- Volume :
- 16
- Database :
- OpenAIRE
- Journal :
- PLOS ONE
- Accession number :
- edsair.doi.dedup.....b5ca061e6acf2bde24a8fe1ed30ddd17