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Standard Operating Procedures for Biospecimen Collection, Processing, and Storage: From the Consortium for the Study of Chronic Pancreatitis, Diabetes, and Pancreatic Cancer
- Source :
- Pancreas. 47(10)
- Publication Year :
- 2018
-
Abstract
- High-quality and well-annotated biorepositories are needed to better understand the pathophysiology and biologic mechanisms of chronic pancreatitis (CP) and its consequences. We report a methodology for the development of a robust standard operating procedure (SOP) for a biorepository based on the experience of the clinical centers within the consortium to study Chronic Pancreatitis, Diabetes and Pancreas Cancer Clinical Centers (CPDPC), supported by the National Cancer Institute and the National Institute for Diabetes and Digestive and Kidney Diseases as a unique multidisciplinary model to study CP, diabetes, and pancreatic cancer in both children and adults. Standard operating procedures from the CPDPC centers were evaluated and consolidated. The literature was reviewed for standard biorepository operating procedures that facilitated downstream molecular analysis. The existing literature on biobanking practices was harmonized with the SOPs from the clinical centers to produce a biorepository for pancreatic research. This article reports the methods and basic principles behind the creation of SOPs to develop a biorepository for the CPDPC. These will serve as a guide for investigators developing biorepositories in pancreas research. Rigorous and meticulous adherence to standardized biospecimen collection will facilitate investigations to better understand the pathophysiology and biologic mechanisms of CP, diabetes, and pancreatic cancer.
- Subjects :
- medicine.medical_specialty
Biomedical Research
Endocrinology, Diabetes and Metabolism
Preservation, Biological
MEDLINE
Guidelines as Topic
Article
Specimen Handling
03 medical and health sciences
0302 clinical medicine
Endocrinology
Pancreatic cancer
Pancreatitis, Chronic
Internal Medicine
Diabetes Mellitus
Medicine
Humans
Intensive care medicine
Child
Biological Specimen Banks
Hepatology
business.industry
Cancer
medicine.disease
Biobank
Pancreatic Neoplasms
Biorepository
medicine.anatomical_structure
030220 oncology & carcinogenesis
Pancreatitis
030211 gastroenterology & hepatology
business
Pancreas
Standard operating procedure
Subjects
Details
- ISSN :
- 15364828
- Volume :
- 47
- Issue :
- 10
- Database :
- OpenAIRE
- Journal :
- Pancreas
- Accession number :
- edsair.doi.dedup.....b5e0b0318d7e39db7923cc7ec7c9e0f3