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CHOROIDAL IMAGING BIOMARKERS TO PREDICT HIGHLY RESPONSIVE AND RESISTANT CASES TREATED WITH STANDARDIZED ANTI-VASCULAR ENDOTHELIAL GROWTH FACTOR REGIMEN IN NEOVASCULAR AGE-RELATED MACULAR DEGENERATION
- Source :
- Retina (Philadelphia, Pa.). 41(10)
- Publication Year :
- 2021
-
Abstract
- Purpose To determine structural predictors of treatment response in neovascular age-related macular degeneration analyzing optical coherence tomography (OCT)-related biomarkers. Methods A retrospective review of patients undergoing treatment for neovascular age-related macular degeneration at a tertiary institute was performed at presentation. High-intensity regimen included eyes on long-term anti-vascular endothelial growth factor treatment with the inability to extend beyond a month without a relapse and needed double the dose of medication (n = 25). Low-intensity regimen had eyes that went into long-term remission after at least three injections and remained dry for more than a year until the last visit (n = 20). Multimodal imaging including fluorescein angiogram, OCT, and comprehensive ocular evaluation were done. Choroidal vascularity index, total choroidal area, luminal area, subfoveal choroidal thickness, choriocapillaris thickness and Haller and Sattler layer thickness were analyzed for statistical significance. Results The groups had no significant difference at baseline in age, gender, incidence of reticular pseudodrusen, polypoidal choroidal vasculopathy feature on OCT, type of choroidal neovascular membrane, and geographic atrophy. Multinomial logistic regression revealed that thicker subfoveal choroidal thickness and larger total choroidal area were the significant predictors of poor response to anti-vascular endothelial growth factor treatment (E = 0.02; P = 0.02; E = 1.82; P = 0.0075). Conclusion Thicker subfoveal choroidal thickness and higher total choroidal area are useful variables to predict a poor treatment response.
- Subjects :
- Indocyanine Green
Male
Vascular Endothelial Growth Factor A
medicine.medical_specialty
Treatment response
genetic structures
Recombinant Fusion Proteins
Drug Resistance
Visual Acuity
Angiogenesis Inhibitors
Retinal Drusen
Multimodal Imaging
Vascularity
Statistical significance
Ophthalmology
Age related
Geographic Atrophy
Medicine
Humans
Fluorescein Angiography
Coloring Agents
Aged
Retrospective Studies
Anti vegf
Aged, 80 and over
business.industry
Choroid
Incidence (epidemiology)
General Medicine
Macular degeneration
medicine.disease
eye diseases
Choroidal Neovascularization
Bevacizumab
Regimen
Receptors, Vascular Endothelial Growth Factor
Treatment Outcome
Intravitreal Injections
Wet Macular Degeneration
Female
sense organs
medicine.symptom
business
Biomarkers
Tomography, Optical Coherence
Follow-Up Studies
Subjects
Details
- ISSN :
- 15392864
- Volume :
- 41
- Issue :
- 10
- Database :
- OpenAIRE
- Journal :
- Retina (Philadelphia, Pa.)
- Accession number :
- edsair.doi.dedup.....b5e22d0dd01bfcb6ababaaf8648f49d4