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New Modalities for Challenging Targets in Drug Discovery

Authors :
Herbert Waldmann
Stéphanie M. Guéret
Tom N. Grossmann
Ranganath Gopalakrishnan
Malin Lemurell
Eric Valeur
Alleyn T. Plowright
Hélène Adihou
Source :
Valeur, E, Guéret, S M, Adihou, H, Gopalakrishnan, R, Lemurell, M, Waldmann, H, Grossmann, T N & Plowright, A T 2017, ' New Modalities for Challenging Targets in Drug Discovery ', Angewandte Chemie International Edition in English, vol. 56, no. 35, pp. 10294–10323 . https://doi.org/10.1002/anie.201611914
Publication Year :
2017

Abstract

An ever increasing understanding of biological systems is providing a range of exciting novel biological targets whose modulation may enable novel therapeutic options in many diseases. These targets include protein-protein and protein-nucleic acid interactions, which are, however, often refractory to classical small molecule approaches. Other types of molecules, or modalities, are therefore required to address these targets, which has led several academic research groups and pharmaceutical companies to increasingly use the concept of so-called 'New Modalities'. This review defines for the first time the scope of this term, which includes novel peptidic scaffolds, oligonucleotides, hybrids, molecular conjugates as well as new uses of classical small molecules. We provide herein a journey through the most representative examples of these modalities to target large binding surface areas such as those found in protein-protein interactions and for biological processes at the center of cell regulation.

Details

Language :
English
ISSN :
05700833
Volume :
56
Issue :
35
Database :
OpenAIRE
Journal :
Angewandte Chemie International Edition in English
Accession number :
edsair.doi.dedup.....b5e4ea67a7c105336e8bd829f572354a
Full Text :
https://doi.org/10.1002/anie.201611914