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Tuberculosis and COVID-19 co-infection: description of the global cohort

Tuberculosis and COVID-19 co-infection: description of the global cohort

Authors :
Migliori, G. B.
Casco, N.
Jorge, A. L.
Palmero, D. J.
Alffenaar, J. -W.
Denholm, J.
Fox, G. J.
Ezz, W.
Cho, J. -G.
Skrahina, A.
Solodovnikova, V.
Bachez, P.
Piubello, A.
Arbex, M. A.
Alves, T.
Rabahi, M. F.
Pereira, G. R.
Sales, R.
Silva, D. R.
Saffie, M. M.
Miranda, R. C.
Cancino, V.
Carbonell, M.
Cisterna, C.
Concha, C.
Cruz, A.
Salinas, N. E.
Revillot, M. E.
Valdes, J. F.
Fernandez, I.
Flores, X.
Tapia, P. G.
Garavagno, A.
Vera, C. G.
Bahamondes, M. H.
Merino, L. M.
Munoz, E.
Munoz, C.
Navarro, I.
Subiabre, J. N.
Ortega, C.
Palma, S.
Pradenas, A. M.
Pereira, G.
Castillo, P. P.
Pinto, M.
Pizarro, R.
Bidegain, F. R.
Rodriguez, P.
Sanchez, C.
Salinas, A. S.
Soto, A.
Taiba, C.
Venegas, M.
Riquelme, M. S. V.
Vilca, E.
Villalon, C.
Yucra, E.
Li, Y.
Guelvez, B.
Plaza, R. V.
Hoyos, K. Y. T.
Andrejak, C.
Blanc, F. -X.
Dourmane, S.
Froissart, A.
Izadifar, A.
Riviere, F.
Schlemmer, F.
Manika, K.
Diallo, B. D.
Hassane-Harouna, S.
Artiles, N.
Mejia, L. A.
Gupta, N.
Ish, P.
Mishra, G.
Sharma, S.
Singla, R.
Udwadia, Z. F.
Alladio, F.
Angeli, F.
Calcagno, A.
Centis, R.
Codecasa, L. R.
D'Ambrosio, L.
De Lauretis, A.
Esposito, S.
Formenti, B.
Gaviraghi, A.
Giacomet, V.
Goletti, D.
Gualano, G.
Matteelli, A.
Motta, I.
Palmieri, F.
Pontali, E.
Prestileo, T.
Riccardi, N.
Saderi, L.
Saporiti, M.
Sotgiu, G.
Stochino, C.
Tadolini, M.
Torre, A.
Villa, S.
Visca, D.
Danila, E.
Diktanas, S.
Ridaura, R. L.
Lopez, F. L. L.
Torrico, M. M.
Rendon, A.
Akkerman, O. W.
Souleymane, M. B.
Al-Abri, S.
Alyaquobi, F.
Althohli, K.
Aizpurua, E.
Gonzales, R.
Jurado, J.
Loban, A.
Aguirre, S.
Teixeira, R. C.
De Egea, V.
Irala, S.
Medina, A.
Sequera, G.
Sosa, N.
Vazquez, F.
Llanos-Tejada, F. K.
Manga, S.
Villanueva-Villegas, R.
Araujo, D.
Duarte, R.
Marques, T. S.
Grecu, V. I.
Socaci, A.
Barkanova, O.
Bogorodskaya, M.
Borisov, S.
Mariandyshev, A.
Kaluzhenina, A.
Vukicevic, T. A.
Stosic, M.
Beh, D.
Ng, D.
Ong, C. W. M.
Solovic, I.
Dheda, K.
Gina, P.
Caminero, J. A.
Cardoso-Landivar, J.
De Souza Galvao, M. L.
Dominguez-Castellano, A.
Garcia-Garcia, J. -M.
Pinargote, I. M.
Fernandez, S. Q.
Sanchez-Montalva, A.
Huguet, E. T.
Murguiondo, M. Z.
Bart, P. -A.
Mazza-Stalder, J.
Bakko, F.
Barnacle, J.
Brown, A.
Chandran, S.
Killington, K.
Man, K.
Papineni, P.
Tiberi, S.
Utjesanovic, N.
Zenner, D.
Hearn, J. L.
Heysell, S.
Young, L.
Source :
The European Respiratory Journal, article-version (AM) Accepted Manuscript
Publication Year :
2021
Publisher :
European Respiratory Society, 2021.

Abstract

BackgroundInformation on tuberculosis (TB) and coronavirus disease 2019 (COVID-19) is still limited. The aim of this study was to describe the features of the TB/COVID-19 co-infected individuals from a prospective, anonymised, multicountry register-based cohort with special focus on the determinants of mortality and other outcomes.MethodsWe enrolled all patients of any age with either active TB or previous TB and COVID-19. 172 centres from 34 countries provided individual data on 767 TB-COVID-19 co-infected patients, (>50% population-based).ResultsOf 767 patients, 553 (74.0%) out of 747 had TB before COVID-19 (including 234 out of 747 with previous TB), 71 (9.5%) out of 747 had COVID-19 first and 123 (16.5%) out of 747 had both diseases diagnosed within the same week (n=35 (4.6%) on the same day). 85 (11.08%) out of 767 patients died (41 (14.2%) out of 289 in Europe and 44 (9.2%) out of 478 outside Europe; p=0.03): 42 (49.4%) from COVID-19, 31 (36.5%) from COVID-19 and TB, one (1.2%) from TB and 11 from other causes. In the univariate analysis on mortality the following variables reached statistical significance: age, male gender, having more than one comorbidity, diabetes mellitus, cardiovascular disease, chronic respiratory disease, chronic renal disease, presence of key symptoms, invasive ventilation and hospitalisation due to COVID-19. The final multivariable logistic regression model included age, male gender and invasive ventilation as independent contributors to mortality.ConclusionThe data suggest that TB and COVID-19 are a “cursed duet” and need immediate attention. TB should be considered a risk factor for severe COVID disease and patients with TB should be prioritised for COVID-19 preventative efforts, including vaccination.

Details

Language :
English
ISSN :
13993003 and 09031936
Database :
OpenAIRE
Journal :
The European Respiratory Journal
Accession number :
edsair.doi.dedup.....b5f72fae7bf777a46f0a61a02f2e7ef4