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Peripheral Blood WT1 Expression Predicts Relapse in AML Patients Undergoing Allogeneic Stem Cell Transplantation
- Source :
- BioMed Research International, Vol 2014 (2014), BioMed Research International
- Publication Year :
- 2014
-
Abstract
- To evaluate if WT1 expression may predict relapse after allo-SCT, we analyzed WT1 levels on peripheral blood (PB) and bone marrow (BM) before and after allo-SCT in 24 AML patients with WT1 overexpression at diagnosis. Five copies of WT1/ABL × 104from PB were identified as the threshold value that correlated with relapse after allo-SCT. The same correlation was not identified when WT1 expression was assessed from bone marrow (BM). Eight out of 11 (73%) patients with a pre-allo-SCT PB-WT1 ≥ 5 and 4/13 (31%) patients with a pre-allo-SCT PB-WT1 < 5 relapsed, respectively (P= 0.04). The incidence of relapse was higher in patients with PB-WT1 ≥ 5 measured after allo-SCT, at the 3rd (56% versus 38%;P= 0.43) and at the 6th month (71% versus 20%;P= 0.03). Patients with pretransplant PB-WT1 < 5 had significantly better 2-year OS and LFS than patients with a PB-WT1 ≥ 5 (81% versus 0% and 63% versus 20%) (P= 0.02). Our data suggest the usefulness of WT1 monitoring from PB to predict the relapse in allotransplanted AML patients and to modulate the intensity of conditioning and/or the posttransplant immunosuppression in an attempt to reduce the posttransplant relapse risk.
- Subjects :
- Adult
medicine.medical_specialty
congenital, hereditary, and neonatal diseases and abnormalities
Myeloid
Article Subject
medicine.medical_treatment
lcsh:Medicine
urologic and male genital diseases
Gastroenterology
General Biochemistry, Genetics and Molecular Biology
Internal medicine
hemic and lymphatic diseases
medicine
Humans
Transplantation, Homologous
WT1 Proteins
General Immunology and Microbiology
business.industry
urogenital system
Incidence (epidemiology)
lcsh:R
Immunosuppression
General Medicine
Middle Aged
Prognosis
medicine.disease
Peripheral blood
female genital diseases and pregnancy complications
Surgery
Transplantation
Leukemia, Myeloid, Acute
Leukemia
Treatment Outcome
medicine.anatomical_structure
Bone marrow
Neoplasm Recurrence, Local
Stem cell
business
Stem Cell Transplantation
Research Article
Subjects
Details
- Language :
- English
- Database :
- OpenAIRE
- Journal :
- BioMed Research International, Vol 2014 (2014), BioMed Research International
- Accession number :
- edsair.doi.dedup.....b5fc0aaf1e8a07227d7e10e5be556d85