Back to Search
Start Over
Synthesis and biological evaluation of new taxoids derived from 2-deacetoxytaxinine J
- Source :
- Bioorganic & Medicinal Chemistry Letters. 17:1579-1583
- Publication Year :
- 2007
- Publisher :
- Elsevier BV, 2007.
-
Abstract
- A small library of 2-deacetoxytaxinine J (DAT-J) 1 derivatives was synthesised and tested in vitro for their reversal activity in human mammary carcinoma MDR cell line MCF7-R. One of the new taxoids showed to be active at 0.1 microM when tested in combination with paclitaxel.
- Subjects :
- Stereochemistry
Clinical Biochemistry
Pharmaceutical Science
Breast Neoplasms
Biochemistry
Chemical synthesis
2-deacetoxytaxinine J
chemistry.chemical_compound
Cell Line, Tumor
Drug Discovery
Humans
Molecular Biology
Organic Chemistry
Biological activity
Antineoplastic Agents, Phytogenic
In vitro
Terpenoid
Paclitaxel
chemistry
Drug Resistance, Neoplasm
Cell culture
Molecular Medicine
Female
Indicators and Reagents
Taxoids
Genes, MDR
Diterpene
Subjects
Details
- ISSN :
- 0960894X
- Volume :
- 17
- Database :
- OpenAIRE
- Journal :
- Bioorganic & Medicinal Chemistry Letters
- Accession number :
- edsair.doi.dedup.....b60dffc1216115075ebf7fed699cca85