Back to Search
Start Over
Heritability of body mass index in pre-adolescence, young adulthood and late adulthood
- Source :
- European Journal of Epidemiology, 27(4), 247-253. Springer Netherlands, Nan, C, Guo, B, Warner, C, Fowler, T, Barrett, T, Boomsma, D I, Nelson, T, Whitfield, K, Beunen, G, Thomis, M, Maes, H H, Derom, C A, Ordoñana, J R, Deeks, J & Zeegers, M P A 2012, ' Heritability of body mass index in pre-adolescence, young adulthood and late adulthood ', European Journal of Epidemiology, vol. 27, no. 4, pp. 247-253 . https://doi.org/10.1007/s10654-012-9678-6, European Journal of Epidemiology, 27(4), 247-253. Springer, Cham
- Publication Year :
- 2010
-
Abstract
- Increased body mass index (BMI) is a worldwide health issue. Individual differences in the susceptibility to increased BMI could be related to genes or environment. We performed a systematic review of genetic studies on BMI in pre-adolescence, young adulthood and late adulthood. We searched PubMed and EMBASE with heritability, body mass index, BMI, weight, height, anthropometry and twins as search terms. Studies reporting intra-pair correlations of healthy twin pairs that were raised together were included. This resulted in the inclusion of 8,179 monozygotic (MZ) and 9,977 dizygotic (DZ) twin pairs from twelve published studies in addition to individual participant data for 629 MZ and 594 DZ pairs from four twin registries. Structural equation modelling with intra-pair twin correlations showed that the heritability of BMI remained high over all age categories ranging from 61 % (95 % CI 54-64 %) to 80 % (95 % CI 76-81 %) for male and female subjects combined, while unique environmental influences increased from 14 % (95 % CI 13-15 %) to 40 % (95 % CI 37-43 %) with increasing age. Heritability of BMI remains consistently high over different age categories. Environmental changes over time do not seem to have as big a relative impact on an individual's weight as previously reported, suggesting a mainly genetic influence on variation in BMI over the years. © Springer-Verlag 2012.
- Subjects :
- Netherlands Twin Register (NTR)
Male
medicine.medical_specialty
Epidemiology
Twins
Life span
FTO gene
Childhood obesity
Body Mass Index
Heritability
ENVIRONMENTAL-INFLUENCES
BMI
Young Adult
medicine
Humans
Obesity
Registries
Young adult
MALE TWINS
FTO GENE
Child
METAANALYSIS
ASSOCIATIONS
Preadolescence
Anthropometry
business.industry
Body Weight
SDG 10 - Reduced Inequalities
Middle Aged
medicine.disease
PHYSICAL-ACTIVITY
Body Composition
ADIPOSITY
Female
WEIGHT
CHILDHOOD OBESITY
business
Body mass index
Demography
Subjects
Details
- ISSN :
- 15737284 and 03932990
- Volume :
- 27
- Issue :
- 4
- Database :
- OpenAIRE
- Journal :
- European journal of epidemiology
- Accession number :
- edsair.doi.dedup.....b624f43727ef1ee4589c4c228e167906