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Effect of Curcumin on Glycaemic and Lipid Parameters in Polycystic Ovary Syndrome: A Systematic Review and Meta-Analysis of Randomized Controlled Trials
- Source :
- Reproductive Sciences. 29:3124-3133
- Publication Year :
- 2021
- Publisher :
- Springer Science and Business Media LLC, 2021.
-
Abstract
- Polycystic ovary syndrome (PCOS) is a heterogeneous condition that affects women of reproductive age. It is associated with menstrual disturbances, hyperandrogenism, and polycystic ovaries. In addition to this, it results in altered anthropometric parameters, insulin resistance, and subsequently untoward cardio-metabolic sequelae. Therapeutic approaches that target weight loss and improve insulin sensitivity are used to address the metabolic complications in PCOS. Curcumin is a phytochemical which exhibits anti-inflammatory and anti-oxidant properties, and therefore, its use in PCOS has been a subject of substantial interest and research. The aim of this study was to synthesize the existing evidence on the effects of curcumin on glycaemic and lipid parameters in PCOS. We searched PubMed, Embase, Web of Science, Scopus, and ClinicalTrials databases from inception to June 07, 2021. Only randomized controlled trials (RCT) presenting sufficient data on glycemic and lipid parameters in patients with PCOS at baseline and the end of the follow-up period in each group were included. Meta-analysis of five RCTs showed a significant reduction on fasting glucose (WMD: − 3.68 mg/dL, 95% CI: − 5.11, − 2.25, p
- Subjects :
- Blood Glucose
medicine.medical_specialty
Curcumin
medicine.medical_treatment
Gastroenterology
law.invention
Insulin resistance
Randomized controlled trial
law
Internal medicine
medicine
Humans
Randomized Controlled Trials as Topic
Glycemic
business.industry
Insulin
Polycystic ovary syndrome (PCOS)
Hyperandrogenism
Obstetrics and Gynecology
medicine.disease
Lipids
Polycystic ovary
Meta-analysis
Female
Insulin Resistance
business
Polycystic Ovary Syndrome
Subjects
Details
- ISSN :
- 19337205 and 19337191
- Volume :
- 29
- Database :
- OpenAIRE
- Journal :
- Reproductive Sciences
- Accession number :
- edsair.doi.dedup.....b64667bfbd1fb6559dbfe3426e1f529f