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MicroRNAs Involved in Metastasis of Hepatocellular Carcinoma: Target Candidates, Functionality and Efficacy in Animal Models and Prognostic Relevance
- Source :
- Cancer Genomics - Proteomics. 17:1-21
- Publication Year :
- 2019
- Publisher :
- Anticancer Research USA Inc., 2019.
-
Abstract
- Hepatocellular carcinoma (HCC) is responsible for the second-leading cancer-related death toll worldwide. Although sorafenib and levantinib as frontline therapy and regorafenib, cabazantinib and ramicurimab have now been approved for second-line therapy, the therapeutic benefit is in the range of only a few months with respect to prolongation of survival. Aggressiveness of HCC is mediated by metastasis. Intrahepatic metastases and distant metastasis to the lungs, lymph nodes, bones, omentum, adrenal gland and brain have been observed. Therefore, the identification of metastasis-related new targets and treatment modalities is of paramount importance. In this review, we focus on metastasis-related microRNAs (miRs) as therapeutic targets for HCC. We describe miRs which mediate or repress HCC metastasis in mouse xenograft models. We discuss 18 metastasis-promoting miRs and 35 metastasis-inhibiting miRs according to the criteria as outlined. Six of the metastasis-promoting miRs (miR-29a, -219-5p, -331-3p, 425-5p, -487a and -1247-3p) are associated with unfavourable clinical prognosis. Another set of six down-regulated miRs (miR-101, -129-3p, -137, -149, -503, and -630) correlate with a worse clinical prognosis. We discuss the corresponding metastasis-related targets as well as their potential as therapeutic modalities for treatment of HCC-related metastasis. A subset of up-regulated miRs -29a, -219-5p and -425-5p and down-regulated miRs -129-3p and -630 were evaluated in orthotopic metastasis-related models which are suitable to mimic HCC-related metastasis. Those miRNAs may represent prioritized targets emerging from our survey.
- Subjects :
- Oncology
Sorafenib
Cancer Research
medicine.medical_specialty
Carcinoma, Hepatocellular
Epithelial-Mesenchymal Transition
Review Article
Biochemistry
Metastasis
03 medical and health sciences
Clinical prognosis
chemistry.chemical_compound
0302 clinical medicine
Mouse xenograft
Cell Movement
Internal medicine
Regorafenib
microRNA
Biomarkers, Tumor
Genetics
medicine
Animals
Humans
Molecular Biology
Cell Proliferation
business.industry
Liver Neoplasms
medicine.disease
Therapeutic modalities
Gene Expression Regulation, Neoplastic
Disease Models, Animal
MicroRNAs
chemistry
030220 oncology & carcinogenesis
Hepatocellular carcinoma
business
Signal Transduction
medicine.drug
Subjects
Details
- ISSN :
- 17906245 and 11096535
- Volume :
- 17
- Database :
- OpenAIRE
- Journal :
- Cancer Genomics - Proteomics
- Accession number :
- edsair.doi.dedup.....b64676a7e0e0328bf74a5fc4a888630f