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Adaptive immunity to human coronaviruses is widespread but low in magnitude
- Source :
- Clinical & Translational Immunology, Vol 10, Iss 3, Pp n/a-n/a (2021), Clinical & Translational Immunology
- Publication Year :
- 2021
-
Abstract
- Objectives Endemic human coronaviruses (hCoVs) circulate worldwide but cause minimal mortality. Although seroconversion to hCoV is near ubiquitous during childhood, little is known about hCoV‐specific T‐cell memory in adults. Methods We quantified CD4 T‐cell and antibody responses to hCoV spike antigens in 42 SARS‐CoV‐2‐uninfected individuals. Antigen‐specific memory T cells and circulating T follicular helper (cTFH) cells were identified using an activation‐induced marker assay and characterised for memory phenotype and chemokine receptor expression. Results T‐cell responses were widespread within conventional memory and cTFH compartments but did not correlate with IgG titres. SARS‐CoV‐2 cross‐reactive T cells were observed in 48% of participants and correlated with HKU1 memory. hCoV‐specific T cells exhibited a CCR6+ central memory phenotype in the blood, but were enriched for frequency and CXCR3 expression in human lung‐draining lymph nodes. Conclusion Overall, hCoV‐specific humoral and cellular memory are independently maintained, with a shared phenotype existing among coronavirus‐specific CD4 T cells. This understanding of endemic coronavirus immunity provides insight into the homeostatic maintenance of immune responses that are likely to be critical components of protection against SARS‐CoV‐2.<br />Adaptive immunity to human coronaviruses includes widespread, low‐level antibody and CD4 T‐cell responses, which are maintained independently. All hCoV‐specific and cross‐reactive SARS‐CoV‐2‐specific CD4 T‐cell responses share a common phenotypic and memory profile. hCoV‐specific CD4 T cells were substantially enriched in human lung‐draining lymph nodes compared with the circulation, suggesting a potential anatomical niche for maintenance of hCoV cellular memory.
- Subjects :
- 0301 basic medicine
lcsh:Immunologic diseases. Allergy
T cell
Immunology
coronavirus
C-C chemokine receptor type 6
Biology
medicine.disease_cause
CXCR3
SARS‐CoV‐2
03 medical and health sciences
0302 clinical medicine
Immune system
Antigen
Immunity
medicine
Immunology and Allergy
Seroconversion
cTFH
General Nursing
Coronavirus
virus diseases
hCoV
Original Articles
CD4 T cell
lymph node
Acquired immune system
030104 developmental biology
medicine.anatomical_structure
Original Article
lcsh:RC581-607
030215 immunology
Subjects
Details
- ISSN :
- 20500068
- Volume :
- 10
- Issue :
- 3
- Database :
- OpenAIRE
- Journal :
- Clinicaltranslational immunology
- Accession number :
- edsair.doi.dedup.....b65b755b51518612ddde7e9276e003ae