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Tenofovir-induced distal renal tubular acidosis: A rare cause of recurrent hypokalaemic paralysis
- Source :
- The journal of the Royal College of Physicians of Edinburgh. 52(2)
- Publication Year :
- 2022
-
Abstract
- Tenofovir disoproxil fumarate was the first nucleotide analogue reverse transcriptase inhibitor to be approved for treatment of human immunodeficiency virus infection. It is a relatively safe drug but can present with nephrotoxicity. We report a case of 36-year-old male who presented with acute onset flaccid paraparesis. He was a diagnosed case of acquired immunodeficiency syndrome for 9 years ago and was on tenofovir-based antiretroviral therapy for last 6 months. As the patient had normal anion gap metabolic acidosis, hypokalaemia and urine pH > 5.5, distal renal tubular acidosis (RTA) was suspected. He improved dramatically within 24 h of hospitalisation after potassium correction to regain normal power. Tenofovir-induced distal RTA presenting as hypokalaemic paralysis is a very rare complication of tenofovir; hence, we are reporting this case. In addition, we suggest regular follow-up of patients taking tenofovir with urine analysis and serum potassium to detect this complication earlier as it is reversible.
Details
- ISSN :
- 20428189
- Volume :
- 52
- Issue :
- 2
- Database :
- OpenAIRE
- Journal :
- The journal of the Royal College of Physicians of Edinburgh
- Accession number :
- edsair.doi.dedup.....b66ba9511734e37f3c2863d95e67b466