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Comparative efficacy and safety of biosimilar infliximab and other biological treatments in ankylosing spondylitis: systematic literature review and meta-analysis
Comparative efficacy and safety of biosimilar infliximab and other biological treatments in ankylosing spondylitis: systematic literature review and meta-analysis
- Source :
- The European Journal of Health Economics
- Publication Year :
- 2014
- Publisher :
- Springer Science and Business Media LLC, 2014.
-
Abstract
- Objectives To compare the efficacy and safety of infliximab-biosimilar with other biological drugs for the treatment of active ankylosing spondylitis (AS). Methods Systematic literature review for randomized controlled trials (RCTs) with adalimumab, etanercept, golimumab, infliximab and infliximab-biosimilar in AS was performed and indirect meta-analysis (Bayesian mixed treatment comparison) was carried out. The proportion of patients reaching 20 % improvement by the assessment of Spondyloarthritis International Society response criteria (ASAS20) at weeks 12 and 24 was used as efficacy endpoints, and the occurrence of serious adverse events at week 24 was applied to compare the safety of the biologicals. Results Altogether, 13 RCTs, identified by the systematic literature search, were included in the analysis. Results on the ASAS20 efficacy endpoint were reported for week 12 in 12 RCTs involving 2,395 patients, and for week 24 in 5 RCTs comprising 1,337 patients. All the five biological agents proved to be significantly superior to placebo. Infliximab showed the highest odds ratio (OR) of 7.2 (95 % CI 3.68–13.19) compared to placebo, followed by infliximab-biosimilar with OR 6.25 (95 % CI 2.55–13.14), both assessed at week 24. No significant difference was found between infliximab-biosimilar and other biological treatments regarding their efficacy and safety. Conclusions This is the first study which includes a biosimilar drug in the meta-analysis of biological treatments in AS. The results have proven the similar efficacy and safety profile of infliximab-biosimilar treatment compared to other biologicals.
- Subjects :
- musculoskeletal diseases
Adult
medicine.medical_specialty
Efficacy
Biological drug
Economics, Econometrics and Finance (miscellaneous)
Klinikai orvostudományok
Biosimilar pharmaceuticals
Biosimilar Pharmaceuticals
medicine
Humans
Spondylitis, Ankylosing
I10
Intensive care medicine
Spondylitis
Randomized Controlled Trials as Topic
Original Paper
Biological Products
Ankylosing spondylitis
business.industry
Health Policy
Antibodies, Monoclonal
Biosimilar
Orvostudományok
Middle Aged
I19
medicine.disease
Infliximab
Antirheumatic Agents
Meta-analysis
Treatment Outcome
Systematic review
Physical therapy
Safety
business
medicine.drug
Subjects
Details
- ISSN :
- 16187601 and 16187598
- Volume :
- 15
- Database :
- OpenAIRE
- Journal :
- The European Journal of Health Economics
- Accession number :
- edsair.doi.dedup.....b67ee735d89da5a299b9a60be7d0848a
- Full Text :
- https://doi.org/10.1007/s10198-014-0593-5