Back to Search
Start Over
The timing of plerixafor addition to G-Csf and chemotherapy affects immunological recovery after autologous stem cell transplant in multiple myeloma
- Publication Year :
- 2019
- Publisher :
- Springer Nature, 2019.
-
Abstract
- Plerixafor inhibits CXCR4, thus inducing the mobilization of hematopoietic stem/progenitor cells in lymphoma and multiple myeloma (MM) patients eligible for autologous stem cell transplantation (ASCT). However, the kinetics of plerixafor-induced mobilization of lymphocyte subsets is poorly known. Here, we evaluated the graft content, the engraftment, and the immunological reconstitution of MM patients receiving plerixafor. Thirty-seven patients undergoing one or tandem ASCT were enrolled. After mobilization with cyclophosphamide plus G-CSF, plerixafor was added at hematological recovery regardless of CD34(+) cell count. We evaluated the number of CD34(+), CD34(+)/CD38(-), CD3(+), CD4(+), CD8(+), CD19(+), CD56(+)/CD3(-), CD4(+)/CD25(+)/FOXP3(+), and CD138(+)/CD38(+) cells on each apheresis. Hematological and immunological recovery were determined at 30 days, 3, 6, 9, and 12 months after ASCT. Overall, 34/37 patients mobilized a median of 10.1 × 10(6) CD34(+) cells/Kg (IQ 7.7-13.4). Patients with
- Subjects :
- Benzylamines
CD34
Pharmacology
CD38
Cyclams
Transplantation, Autologous
CXCR4
03 medical and health sciences
0302 clinical medicine
Autologous stem-cell transplantation
Heterocyclic Compounds
Granulocyte Colony-Stimulating Factor
medicine
Humans
Progenitor cell
Multiple myeloma
plerixafor G-Csf chemotherapy immunological recovery after autologous stem cell transplant multiple myeloma
Transplantation
business.industry
Plerixafor
Hematopoietic Stem Cell Transplantation
Hematology
medicine.disease
Hematopoietic Stem Cell Mobilization
030220 oncology & carcinogenesis
Stem cell
Multiple Myeloma
business
030215 immunology
medicine.drug
Subjects
Details
- Language :
- English
- Database :
- OpenAIRE
- Accession number :
- edsair.doi.dedup.....b68588ab0c0ceae1e07821073e978145