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Adverse Drug Reactions of Spontaneous Reports in Shanghai Pediatric Population
- Source :
- PLoS ONE, PLoS ONE, Vol 9, Iss 2, p e89829 (2014)
- Publication Year :
- 2014
- Publisher :
- Public Library of Science (PLoS), 2014.
-
Abstract
- Background Knowledge of drug safety in the pediatric population of China is limited. This study was designed to evaluate ADRs in children reported to the spontaneous reporting system (SRS) of Shanghai in 2009. Methodology and Principal Findings Crude ADR reports submitted to Shanghai SRS in 2009 for individuals aged from birth to 17 years (including 17 years) were included. Data were analyzed with respect to age, gender, category of ADR (System Organ Class [SOC]), the severity of reports and type of reporter. Results A male overrepresentation was observed regarding the total number of reports. The most frequently reported group of drugs were vaccines (42.15%). Skin rash and fever were the commonest symptoms reported in the total pediatric dataset. The proportion of children that suffered from a serious ADR was 2.16% and that for drug related deaths was 0.34%. And we found that the multiple drug exposure experienced a high proportion of serious ADRs compared with the single drug use (χ2 = 15.99, P
- Subjects :
- Male
Pediatrics
Epidemiology
lcsh:Medicine
Pediatric Dermatology
Toxicology
Sex factors
lcsh:Science
Child
Pediatric Epidemiology
media_common
Vaccines
Multidisciplinary
Vaccination
Age Factors
Child, Preschool
Spontaneous reporting
Medicine
Female
Public Health
Research Article
Drug
China
Drugs and Devices
medicine.medical_specialty
Adolescent
Drug-Related Side Effects and Adverse Reactions
media_common.quotation_subject
Community participation
MEDLINE
Dermatology
Sex Factors
parasitic diseases
medicine
Humans
Drug reaction
Biology
business.industry
lcsh:R
Community Participation
Infant, Newborn
Immunity
Infant
Infant newborn
Logistic Models
lcsh:Q
Clinical Immunology
business
Pediatric population
Subjects
Details
- ISSN :
- 19326203
- Volume :
- 9
- Database :
- OpenAIRE
- Journal :
- PLoS ONE
- Accession number :
- edsair.doi.dedup.....b68a4eb86a23f8121129bd2d69944c14