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Tenectin is a novel alphaPS2betaPS integrin ligand required for wing morphogenesis and male genital looping in Drosophila
- Source :
- Developmental Biology, Developmental Biology, Elsevier, 2010, 340 (2), pp.504-17. ⟨10.1016/j.ydbio.2010.02.008⟩, Developmental Biology, Elsevier, 2010, 340 (2), pp.504-17. 〈10.1016/j.ydbio.2010.02.008〉
- Publication Year :
- 2010
- Publisher :
- HAL CCSD, 2010.
-
Abstract
- International audience; Morphogenesis of the adult structures of holometabolous insects is regulated by ecdysteroids and juvenile hormones and involves cell-cell interactions mediated in part by the cell surface integrin receptors and their extracellular matrix (ECM) ligands. These adhesion molecules and their regulation by hormones are not well characterized. We describe the gene structure of a newly described ECM molecule, tenectin, and demonstrate that it is a hormonally regulated ECM protein required for proper morphogenesis of the adult wing and male genitalia. Tenectin's function as a new ligand of the PS2 integrins is demonstrated by both genetic interactions in the fly and by cell spreading and cell adhesion assays in cultured cells. Its interaction with the PS2 integrins is dependent on RGD and RGD-like motifs. Tenectin's function in looping morphogenesis in the development of the male genitalia led to experiments that demonstrate a role for PS integrins in the execution of left-right asymmetry.
- Subjects :
- Male
MESH: Extracellular Matrix Proteins
MESH: Drosophila
MESH : Immunohistochemistry
[ SDV.AEN ] Life Sciences [q-bio]/Food and Nutrition
Integrin
Ligands
Looping morphogenesis
Extracellular matrix
chemistry.chemical_compound
0302 clinical medicine
MESH: Genitalia, Male
Morphogenesis
MESH: Ligands
Drosophila Proteins
Wings, Animal
MESH: Animals
Transgenes
In Situ Hybridization
0303 health sciences
Extracellular Matrix Proteins
MESH : Genitalia, Male
MESH : Ligands
Integrin alpha Chains
Cell adhesion molecule
MESH : In Situ Hybridization
Immunohistochemistry
3. Good health
Cell biology
Larva
MESH : Integrin alpha Chains
Adhesion
Drosophila
MESH : Mutation
MESH : Transgenes
Tenectin
Drosophila Protein
Ecdysone
MESH: Mutation
MESH: Drosophila Proteins
MESH : Male
MESH : Wing
MESH: Transgenes
Biology
Genitalia, Male
Article
03 medical and health sciences
MESH : Extracellular Matrix Proteins
MESH: In Situ Hybridization
Animals
MESH : Drosophila
Cell adhesion
Molecular Biology
030304 developmental biology
MESH : Larva
Metamorphosis
MESH: Integrin alpha Chains
Left–right asymmetry
MESH: Immunohistochemistry
Cell Biology
MESH : Drosophila Proteins
MESH: Wing
MESH: Male
MESH: Morphogenesis
chemistry
MESH : Morphogenesis
Mutation
biology.protein
MESH : Animals
MESH: Larva
[SDV.AEN]Life Sciences [q-bio]/Food and Nutrition
030217 neurology & neurosurgery
Developmental Biology
Subjects
Details
- Language :
- English
- ISSN :
- 00121606 and 1095564X
- Database :
- OpenAIRE
- Journal :
- Developmental Biology, Developmental Biology, Elsevier, 2010, 340 (2), pp.504-17. ⟨10.1016/j.ydbio.2010.02.008⟩, Developmental Biology, Elsevier, 2010, 340 (2), pp.504-17. 〈10.1016/j.ydbio.2010.02.008〉
- Accession number :
- edsair.doi.dedup.....b6add8ffb22d48f931bcd5d961aee51f