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Tenectin is a novel alphaPS2betaPS integrin ligand required for wing morphogenesis and male genital looping in Drosophila

Authors :
Anne-Laure Bougé
Thomas A. Bunch
Timmy Kendall
Stéphane Fraichard
Isabelle Chauvel
Hervé Bouhin
Centre des Sciences du Goût et de l'Alimentation [Dijon] (CSGA)
Institut National de la Recherche Agronomique (INRA)-Université de Bourgogne (UB)-AgroSup Dijon - Institut National Supérieur des Sciences Agronomiques, de l'Alimentation et de l'Environnement-Centre National de la Recherche Scientifique (CNRS)
Centre des Sciences du Goût et de l'Alimentation [Dijon] ( CSGA )
Institut National de la Recherche Agronomique ( INRA ) -Université de Bourgogne ( UB ) -AgroSup Dijon - Institut National Supérieur des Sciences Agronomiques, de l'Alimentation et de l'Environnement-Centre National de la Recherche Scientifique ( CNRS )
Source :
Developmental Biology, Developmental Biology, Elsevier, 2010, 340 (2), pp.504-17. ⟨10.1016/j.ydbio.2010.02.008⟩, Developmental Biology, Elsevier, 2010, 340 (2), pp.504-17. 〈10.1016/j.ydbio.2010.02.008〉
Publication Year :
2010
Publisher :
HAL CCSD, 2010.

Abstract

International audience; Morphogenesis of the adult structures of holometabolous insects is regulated by ecdysteroids and juvenile hormones and involves cell-cell interactions mediated in part by the cell surface integrin receptors and their extracellular matrix (ECM) ligands. These adhesion molecules and their regulation by hormones are not well characterized. We describe the gene structure of a newly described ECM molecule, tenectin, and demonstrate that it is a hormonally regulated ECM protein required for proper morphogenesis of the adult wing and male genitalia. Tenectin's function as a new ligand of the PS2 integrins is demonstrated by both genetic interactions in the fly and by cell spreading and cell adhesion assays in cultured cells. Its interaction with the PS2 integrins is dependent on RGD and RGD-like motifs. Tenectin's function in looping morphogenesis in the development of the male genitalia led to experiments that demonstrate a role for PS integrins in the execution of left-right asymmetry.

Details

Language :
English
ISSN :
00121606 and 1095564X
Database :
OpenAIRE
Journal :
Developmental Biology, Developmental Biology, Elsevier, 2010, 340 (2), pp.504-17. ⟨10.1016/j.ydbio.2010.02.008⟩, Developmental Biology, Elsevier, 2010, 340 (2), pp.504-17. 〈10.1016/j.ydbio.2010.02.008〉
Accession number :
edsair.doi.dedup.....b6add8ffb22d48f931bcd5d961aee51f