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Knockout of Pannexin-1 Induces Hearing Loss
- Source :
- International Journal of Molecular Sciences, Vol 19, Iss 5, p 1332 (2018), International Journal of Molecular Sciences; Volume 19; Issue 5; Pages: 1332, International Journal of Molecular Sciences
- Publication Year :
- 2018
- Publisher :
- MDPI AG, 2018.
-
Abstract
- Mutations of gap junction connexin genes induce a high incidence of nonsyndromic hearing loss. Pannexin genes also encode gap junctional proteins in vertebrates. Recent studies demonstrated that Pannexin-1 (Panx1) deficiency in mice and mutation in humans are also associated with hearing loss. So far, several Panx1 knockout (KO) mouse lines were established. In general, these Panx1 KO mouse lines demonstrate consistent phenotypes in most aspects, including hearing loss. However, a recent study reported that a Panx1 KO mouse line, which was created by Genentech Inc., had no hearing loss as measured by the auditory brainstem response (ABR) threshold at low-frequency range (
- Subjects :
- Male
0301 basic medicine
inner ear
Otoacoustic emission
Connexin
medicine.disease_cause
Connexins
lcsh:Chemistry
Mice
0302 clinical medicine
Panx1
deafness
hearing
gap junction
ABR
DPOAE
CM
lcsh:QH301-705.5
Spectroscopy
Mutation
Gap junction
Gap Junctions
General Medicine
Pannexin
Cochlea
Computer Science Applications
medicine.anatomical_structure
Female
medicine.symptom
medicine.medical_specialty
Hearing loss
Nerve Tissue Proteins
Biology
Article
Catalysis
Inorganic Chemistry
03 medical and health sciences
Internal medicine
Evoked Potentials, Auditory, Brain Stem
medicine
otorhinolaryngologic diseases
Animals
Inner ear
Physical and Theoretical Chemistry
Hearing Loss
Molecular Biology
Organic Chemistry
Mice, Inbred C57BL
030104 developmental biology
Auditory brainstem response
Endocrinology
lcsh:Biology (General)
lcsh:QD1-999
030217 neurology & neurosurgery
Subjects
Details
- Language :
- English
- ISSN :
- 14220067
- Volume :
- 19
- Issue :
- 5
- Database :
- OpenAIRE
- Journal :
- International Journal of Molecular Sciences
- Accession number :
- edsair.doi.dedup.....b6b2fbeb254508e24082d635ffc5e9c7