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The relationship between heart rate variability and inflammatory markers in cardiovascular diseases
- Source :
- Psychoneuroendocrinology. 33:1305-1312
- Publication Year :
- 2008
- Publisher :
- Elsevier BV, 2008.
-
Abstract
- Summary Introduction Recent evidence implicates a cholinergic anti-inflammatory pathway. Because vagus nerve activity mediates some heart rate variability (HRV), this qualitative review examines the literature concerning circulating cytokines and HRV in cardiovascular function in humans. This qualitative review examines the literature concerning circulating cytokines and HRV in cardiovascular function in humans. Methods Thirteen studies on HRV, inflammation, and cardiovascular function were located by electronic library search and descriptively reviewed. Results The relationship between HRV and inflammation was studied in healthy controls, patients with acute or stable coronary heart disease (CHD), patients with metabolic syndrome or impaired glucose tolerance and patients with kidney failure. Investigations focused mainly on Interleukin-6 (IL-6) and C-reactive peptide (CRP). The majority of reviewed studies reported that parasympathetic nervous system tone as inferred from heart rate variability is inversely related to inflammatory markers ( r values between −0.2 and −0.4). The relationships with inflammatory markers were similar whether derived from ECG signals as short as 5–30 min or from 24-h ECG readings for HRV analyses. While inflammatory markers appear to be related to HRV, it is a mistake to assume that the traditional “vagal measures” of HRV (such as high frequency heart rate variability) are the driving factors. Indeed, low frequency heart rate variability, a complex measure reflecting both parasympathetic and sympathetic activity, is the more commonly associated measure linked to inflammatory markers. Discussion Heart rate variability is inversely correlated with inflammatory markers in healthy individuals as well as in those with cardiovascular diseases.
- Subjects :
- medicine.medical_specialty
Endocrinology, Diabetes and Metabolism
Coronary Disease
Inflammation
Article
Impaired glucose tolerance
Parasympathetic nervous system
Endocrinology
Heart Rate
Internal medicine
Glucose Intolerance
Heart rate
medicine
Humans
Heart rate variability
Biological Psychiatry
Metabolic Syndrome
Endocrine and Autonomic Systems
business.industry
medicine.disease
Vagus nerve
Psychiatry and Mental health
Autonomic nervous system
medicine.anatomical_structure
Cardiovascular Diseases
Cardiology
Kidney Diseases
Metabolic syndrome
medicine.symptom
business
Biomarkers
Subjects
Details
- ISSN :
- 03064530
- Volume :
- 33
- Database :
- OpenAIRE
- Journal :
- Psychoneuroendocrinology
- Accession number :
- edsair.doi.dedup.....b6ca3d85dd2a1a9d284a17c3d8a7e2e2
- Full Text :
- https://doi.org/10.1016/j.psyneuen.2008.08.007