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Twenty-Eight Cases of Extraocular Sebaceous Carcinoma: A Correlative Clinicopathological and Immunohistochemical Analysis of Extraocular Sebaceous Carcinomas and Benign Sebaceous Gland Tumors
- Source :
- The American Journal of Dermatopathology. 43:93-102
- Publication Year :
- 2020
- Publisher :
- Ovid Technologies (Wolters Kluwer Health), 2020.
-
Abstract
- Extraocular sebaceous carcinoma (ESC) is a rare appendiceal skin tumor. In contrast to ocular sebaceous carcinoma, information about the exact cellular architecture of these lesions is scarce and the histogenesis of ESC is unknown. Here, we extend our previous study and investigate 28 extraocular carcinomas in comparison to 54 benign sebaceous tumors and 8 cases of normal sebaceous glands using a broad spectrum of antibodies against p63, several keratins, adipophilin, EMA, Ki67, androgen receptor, and mismatch repair proteins. This observational study demonstrates that p63- and K5/14-positive basaloid cells are key cells in normal sebaceous gland and in all sebaceous tumors and that these basaloid cells give rise to EMA+, adipophilin+ sebocytes, and K5/14+, K7±, K10± ductal structures. Finally, about half of ESC is associated with superficial in situ neoplasia, which provides evidence that at least part of these carcinomas arises from flat superficial in situ carcinoma. In contrast to the normal sebaceous gland, about half of all sebaceous tumors lack keratin K7. MMR protein IHC-profiles role will be discussed.
- Subjects :
- Adenoma
Adult
Male
Sebaceous gland
Pathology
medicine.medical_specialty
Biopsy
Dermatology
Histogenesis
Pathology and Forensic Medicine
030207 dermatology & venereal diseases
03 medical and health sciences
0302 clinical medicine
Predictive Value of Tests
Keratin
Biomarkers, Tumor
Carcinoma
Humans
Medicine
Sebaceous Gland Neoplasms
Aged
Aged, 80 and over
chemistry.chemical_classification
business.industry
General Medicine
Middle Aged
Normal sebaceous glands
medicine.disease
Immunohistochemistry
Androgen receptor
medicine.anatomical_structure
chemistry
Female
business
Sebaceous carcinoma
Subjects
Details
- ISSN :
- 01931091
- Volume :
- 43
- Database :
- OpenAIRE
- Journal :
- The American Journal of Dermatopathology
- Accession number :
- edsair.doi.dedup.....b6d0ba333c051c35cfa4be81e8455430