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C O bond formation in a microfluidic reactor: high yield S N Ar substitution of heteroaryl chlorides

Authors :
Jesus Campagna
Patricia Spilman
Varghese John
Mohammad Parvez Alam
Jagodzinska Barbara
Source :
Tetrahedron Letters. 57:2059-2062
Publication Year :
2016
Publisher :
Elsevier BV, 2016.

Abstract

This study describes our development of a novel and efficient procedure for C-O bond formation under mild conditions, for coupling heteroaryl chlorides with phenols or primary aliphatic alcohols. We utilized a continuous-flow microfluidic reactor for C-O bond formation in electron-deficient pyrimidines and pyridines in a much more facile manner with a cleaner reaction profile, high yield, quick scalability and without the need for the transition metal catalyst. This approach can be of general utility to make C-O bond containing intermediates of industrial importance in a continuous and safe manner.

Details

ISSN :
00404039
Volume :
57
Database :
OpenAIRE
Journal :
Tetrahedron Letters
Accession number :
edsair.doi.dedup.....b6db6147b2279740103ccc28e8bb621a
Full Text :
https://doi.org/10.1016/j.tetlet.2016.03.095