Back to Search
Start Over
C O bond formation in a microfluidic reactor: high yield S N Ar substitution of heteroaryl chlorides
- Source :
- Tetrahedron Letters. 57:2059-2062
- Publication Year :
- 2016
- Publisher :
- Elsevier BV, 2016.
-
Abstract
- This study describes our development of a novel and efficient procedure for C-O bond formation under mild conditions, for coupling heteroaryl chlorides with phenols or primary aliphatic alcohols. We utilized a continuous-flow microfluidic reactor for C-O bond formation in electron-deficient pyrimidines and pyridines in a much more facile manner with a cleaner reaction profile, high yield, quick scalability and without the need for the transition metal catalyst. This approach can be of general utility to make C-O bond containing intermediates of industrial importance in a continuous and safe manner.
- Subjects :
- Primary (chemistry)
010405 organic chemistry
Organic Chemistry
Microfluidics
Flow chemistry
Bond formation
010402 general chemistry
01 natural sciences
Biochemistry
Combinatorial chemistry
Article
0104 chemical sciences
Catalysis
chemistry.chemical_compound
chemistry
Transition metal
Yield (chemistry)
Drug Discovery
Organic chemistry
Phenols
Subjects
Details
- ISSN :
- 00404039
- Volume :
- 57
- Database :
- OpenAIRE
- Journal :
- Tetrahedron Letters
- Accession number :
- edsair.doi.dedup.....b6db6147b2279740103ccc28e8bb621a
- Full Text :
- https://doi.org/10.1016/j.tetlet.2016.03.095