Fatal complications of virus hepatitis in two patients with agammaglobulinemia

Two patients with agammaglobulinemia who died of complications of a disease presumed to be homologous serum hepatitis are described. The occurrence of acute atrophy in one patient and typical postnecrotic cirrhosis in the other has induced critical evaluation of the concept that an autoimmune mechanism is important in the pathogenesis of either of these complications of virus hepatitis.