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Genetic Polymorphisms of Interleukin-1 Alpha and the Vitamin D Receptor in Mexican Mestizo Patients with Intervertebral Disc Degeneration
Genetic Polymorphisms of Interleukin-1 Alpha and the Vitamin D Receptor in Mexican Mestizo Patients with Intervertebral Disc Degeneration
- Source :
- International Journal of Genomics, Vol 2014 (2014), International Journal of Genomics
- Publication Year :
- 2014
- Publisher :
- Hindawi Publishing Corporation, 2014.
-
Abstract
- Intervertebral disc degeneration (IDD) is the most common diagnosis in patients with back pain, a leading cause of musculoskeletal disability worldwide. Several conditions, such as occupational activities, gender, age, and obesity, have been associated with IDD. However, the development of this disease has strong genetic determinants. In this study, we explore the possible association between rs1800587 (c.-949C>T) of interleukin-1 alpha (IL1A) and rs2228570 (c.2T>V) and rs731236 (c.1056T>C) of vitamin D receptor (VDR) gene polymorphisms and the development of IDD in northwestern Mexican Mestizo population. Gene polymorphisms were analyzed by polymerase chain reaction followed by restriction fragment length polymorphism, in two groups matched by age and gender: patients with symptomatic lumbar IDDn=100and subjects with normal lumbar-spine MRI-scansn=100. Distribution of the mutated alleles in patients and controls was 27.0% versus 28.0%P=0.455for T of rs1800587 (IL1A); 53.0% versus 58.0%P=0.183for V of rs2228570 (VDR); and 18.0% versus 21.0%P=0.262for C of rs731236 (VDR). Our results showed no association between the studied polymorphisms and IDD in this population. This is the first report on the contribution of gene polymorphisms on IDD in a Mexican population.
- Subjects :
- medicine.medical_specialty
education.field_of_study
lcsh:QH426-470
Article Subject
business.industry
Population
Pharmaceutical Science
Alpha (ethology)
Interleukin
medicine.disease
Biochemistry
Gastroenterology
Calcitriol receptor
Obesity
lcsh:Genetics
IL1A
Internal medicine
Genetics
medicine
Allele
Restriction fragment length polymorphism
business
education
Molecular Biology
Research Article
Subjects
Details
- Language :
- English
- ISSN :
- 2314436X
- Database :
- OpenAIRE
- Journal :
- International Journal of Genomics
- Accession number :
- edsair.doi.dedup.....b6ec7fb2a67d3d482c6f78b616241786
- Full Text :
- https://doi.org/10.1155/2014/302568