Back to Search
Start Over
Pomace Olive Oil Improves Endothelial Function in Spontaneously Hypertensive Rats by Increasing Endothelial Nitric Oxide Synthase Expression
- Source :
- idUS. Depósito de Investigación de la Universidad de Sevilla, instname, Digital.CSIC. Repositorio Institucional del CSIC, idUS: Depósito de Investigación de la Universidad de Sevilla, Universidad de Sevilla (US)
- Publication Year :
- 2007
- Publisher :
- Oxford University Press (OUP), 2007.
-
Abstract
- BACKGROUND: The effect of dietary pomace olive oil, which has the same concentration of oleic acid but a higher proportion of oleanolic acid (OA) than olive oil, was examined on animal models of hypertension for the first time. METHODS: During 12 weeks, Wistar Kyoto (WKY) and spontaneously hypertensive rats (SHR) were fed with either a control 2% corn oil diet (BD), or high-fat diets containing 15% of refined olive oil (OL), pomace olive oil (POM), or pomace olive oil supplemented in OA (up to 800 ppm) (POMO). Then, vascular reactivity and endothelial nitric oxide (NO) synthase (eNOS) expression were studied in aortic rings. Plasma nitrite + nitrate levels were also determined. RESULTS: Diets had no effects on blood pressure (BP). In contrast to the BD and OL dietary groups, POM intake improved relaxation evoked by acetylcholine in SHR aorta. The POMO intake increased vasodilatation to acetylcholine and attenuated phenylephrine-induced contractions in both strains of rats associated with a major NO participation revealed by inhibition of NOS. The enhanced relaxation shown in POM and POMO SHR aorta was attributed to an increased eNOS protein expression. Plasma nitrite levels were also increased in these groups. Although olive and pomace oils used in diets contained similar fatty acid composition, beneficial effects on endothelial function were absent in the OL group. Therefore, these effects must be associated with some minor components from pomace olive oil such as OA. CONCLUSIONS: Chronic intake of diets rich in pomace olive oil improves endothelial dysfunction in SHR aorta by mechanisms associated with enhanced eNOS expression. Important evidence is provided regarding the effects of pomace olive oil and OA on endothelial function in hypertensive animals.
- Subjects :
- Male
medicine.medical_specialty
Nitric Oxide Synthase Type III
Endothelium
Rats, Inbred WKY
Muscle, Smooth, Vascular
Nitric oxide
chemistry.chemical_compound
Spontaneously hypertensive rat
Rats, Inbred SHR
Internal medicine
Internal Medicine
medicine
Animals
Plant Oils
Pomace olive oil
Olive Oil
Oleanolic acid
biology
business.industry
Pomace
Endothelial function
Rats
Plants oils
Nitric oxide synthase
Oleic acid
Endocrinology
medicine.anatomical_structure
chemistry
Muscle contraction
Hypertension
Prostaglandins
biology.protein
Endothelium, Vascular
business
Corn oil
Subjects
Details
- ISSN :
- 08957061
- Volume :
- 20
- Database :
- OpenAIRE
- Journal :
- American Journal of Hypertension
- Accession number :
- edsair.doi.dedup.....b6eff9295fe5f0d86740cf98f3d07790