Back to Search
Start Over
Resolvin D1 Reduces Emphysema and Chronic Inflammation
- Source :
- The American journal of pathology. 185(12)
- Publication Year :
- 2015
-
Abstract
- Chronic obstructive pulmonary disease is characterized, in part, by chronic inflammation that persists even after smoking cessation, suggesting that a failure to resolve inflammation plays an important role in the pathogenesis of the disease. It is widely recognized that the resolution of inflammation is an active process, governed by specialized proresolving lipid mediators, including lipoxins, resolvins, maresins, and protectins. Here, we report that proresolving signaling and metabolic pathways are disrupted in lung tissue from patients with chronic obstructive pulmonary disease, suggesting that supplementation with proresolving lipid mediators might reduce the development of emphysema by controlling chronic inflammation. Groups of mice were exposed long-term to cigarette smoke and treated with the proresolving mediator resolvin D1. Resolvin D1 was associated with a reduced development of cigarette smoke-induced emphysema and airspace enlargement, with concurrent reductions in inflammation, oxidative stress, and cell death. Interestingly, resolvin D1 did not promote the differentiation of M2 macrophages and did not promote tissue fibrosis. Taken together, our results suggest that cigarette smoking disrupts endogenous proresolving pathways and that supplementation with specialized proresolving lipid mediators is an important therapeutic strategy in chronic lung disease, especially if endogenous specialized proresolving lipid mediator signaling is impaired.
- Subjects :
- Adult
Male
Programmed cell death
Docosahexaenoic Acids
Drug Evaluation, Preclinical
Inflammation
Apoptosis
Disease
medicine.disease_cause
Pathology and Forensic Medicine
Pathogenesis
Pulmonary Disease, Chronic Obstructive
Mediator
Macrophages, Alveolar
Medicine
Animals
Humans
Aged
Aged, 80 and over
business.industry
Anti-Inflammatory Agents, Non-Steroidal
Smoking
Regular Article
Lipid signaling
Pneumonia
Middle Aged
Mice, Inbred C57BL
Oxidative Stress
Pulmonary Emphysema
Immunology
Chronic Disease
Female
medicine.symptom
Signal transduction
business
Oxidative stress
Signal Transduction
Subjects
Details
- ISSN :
- 15252191
- Volume :
- 185
- Issue :
- 12
- Database :
- OpenAIRE
- Journal :
- The American journal of pathology
- Accession number :
- edsair.doi.dedup.....b6f1d2c39de9a4479f166bc0e16d040e