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The impact of lymph node dissection on apparent Stage I epithelial ovarian carcinoma: A populationābased study
- Source :
- International Journal of Gynecology & Obstetrics. 154:550-557
- Publication Year :
- 2021
- Publisher :
- Wiley, 2021.
-
Abstract
- Objective To explore the impact of lymphadenectomy on the prognosis of women of reproductive age with clinically apparent Stage I epithelial ovarian cancer (EOC). Methods Data of women of reproductive age with Stage I EOC, diagnosed between 2010 and 2016, were extracted from the Surveillance, Epidemiology, and End Results database. Five-year cancer-specific survival (CSS) was evaluated using the Kaplan-Meier method. Multivariate Cox analysis was performed to evaluate the effect of lymph node dissection on survival. Propensity score (PS) matching was conducted to balance various clinicopathologic factors. Results Of 2222 patients included, 1609 (72.4%) received lymph node dissection. The rate of histopathologically confirmed lymph node metastasis was highest in serous subtype (10.2%) and lowest in mucinous subtype (2.2%). No significant difference between the lymphadenectomy and non-lymphadenectomy groups in 5-year CSS was observed in the original cohort (P = 0.364) or in the PS matching cohort (P = 0.248). Nevertheless, there was a significant difference between the lymphadenectomy and non-lymphadenectomy groups for patients with Stage IC EOC (92.4% vs. 88.1%, P = 0.027). According to the multivariate analysis, performance of the lymphadenectomy was not significantly associated with CSS in the original cohort (P = 0.163) or the PS matching cohort (P = 0.101). Conclusion Dissection of lymph nodes was not significantly associated with improved prognosis for most Stage I EOC, but, lymphadenectomy may be necessary for women of reproductive age with Stage IC subtype.
- Subjects :
- Oncology
medicine.medical_specialty
medicine.medical_treatment
Carcinoma, Ovarian Epithelial
03 medical and health sciences
0302 clinical medicine
Internal medicine
medicine
Humans
030212 general & internal medicine
Stage (cooking)
Lymph node
Neoplasm Staging
Retrospective Studies
Ovarian Neoplasms
030219 obstetrics & reproductive medicine
business.industry
Obstetrics and Gynecology
General Medicine
Prognosis
Dissection
Serous fluid
medicine.anatomical_structure
Propensity score matching
Cohort
Lymph Node Excision
Female
Lymphadenectomy
Lymph Nodes
Lymph
business
Subjects
Details
- ISSN :
- 18793479 and 00207292
- Volume :
- 154
- Database :
- OpenAIRE
- Journal :
- International Journal of Gynecology & Obstetrics
- Accession number :
- edsair.doi.dedup.....b7073d5376e401aee7b0f995f895a9cb