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Hepatic Sinusoidal Obstruction Syndrome Induced by Non-transplant Chemotherapy for Non-Hodgkin Lymphoma
Hepatic Sinusoidal Obstruction Syndrome Induced by Non-transplant Chemotherapy for Non-Hodgkin Lymphoma
- Source :
- Internal Medicine
- Publication Year :
- 2017
-
Abstract
- Hepatic sinusoidal obstruction syndrome (SOS), a serious complication that mainly occurs after hematopoietic-stem cell transplantation (HSCT), is caused by damage to the sinusoidal endothelial cells after the obstruction of the sinusoid. Recently, hepatic SOS was reported to occur after non-HSCT chemotherapies. This report describes a patient who experienced hepatic SOS after non-HSCT chemotherapy for non-Hodgkin lymphoma. A liver biopsy showed the slight dilatation of the hepatic sinusoid, which may be indicative of hepatic SOS. Hepatic SOS should be included in the differential diagnosis of patients with severe liver injury following the administration of chemotherapy regimens that are toxic to the vascular endothelial cells.
- Subjects :
- Oncology
Male
medicine.medical_specialty
medicine.medical_treatment
Biopsy
Hepatic Veno-Occlusive Disease
Case Report
chemotherapy
Gastroenterology
jaundice
03 medical and health sciences
0302 clinical medicine
Sinusoid
Fatal Outcome
immune system diseases
Internal medicine
hemic and lymphatic diseases
Antineoplastic Combined Chemotherapy Protocols
Internal Medicine
medicine
Humans
Liver injury
Chemotherapy
medicine.diagnostic_test
business.industry
Hematopoietic Stem Cell Transplantation
General Medicine
biochemical phenomena, metabolism, and nutrition
Middle Aged
medicine.disease
Lymphoma
sinusoidal obstruction syndrome
surgical procedures, operative
Liver
030220 oncology & carcinogenesis
Liver biopsy
Hodgkin lymphoma
bacteria
cyclophosphamide
Lymphoma, Large B-Cell, Diffuse
Differential diagnosis
business
Complication
Tomography, X-Ray Computed
drug-induced liver injury
030215 immunology
Subjects
Details
- ISSN :
- 13497235
- Volume :
- 56
- Issue :
- 4
- Database :
- OpenAIRE
- Journal :
- Internal medicine (Tokyo, Japan)
- Accession number :
- edsair.doi.dedup.....b70e38cbb4a4b8f0ef544ff4886d7137