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Hepatic Sinusoidal Obstruction Syndrome Induced by Non-transplant Chemotherapy for Non-Hodgkin Lymphoma

Hepatic Sinusoidal Obstruction Syndrome Induced by Non-transplant Chemotherapy for Non-Hodgkin Lymphoma

Authors :
Toshiro Sugiyama
Takayoshi Miyazono
Shigeharu Miwa
Miho Sakumura
Kotaro Arita
Kengo Kawai
Kohei Nagata
Jun Murakami
Akinori Wada
Kazuto Tajiri
Source :
Internal Medicine
Publication Year :
2017

Abstract

Hepatic sinusoidal obstruction syndrome (SOS), a serious complication that mainly occurs after hematopoietic-stem cell transplantation (HSCT), is caused by damage to the sinusoidal endothelial cells after the obstruction of the sinusoid. Recently, hepatic SOS was reported to occur after non-HSCT chemotherapies. This report describes a patient who experienced hepatic SOS after non-HSCT chemotherapy for non-Hodgkin lymphoma. A liver biopsy showed the slight dilatation of the hepatic sinusoid, which may be indicative of hepatic SOS. Hepatic SOS should be included in the differential diagnosis of patients with severe liver injury following the administration of chemotherapy regimens that are toxic to the vascular endothelial cells.

Details

ISSN :
13497235
Volume :
56
Issue :
4
Database :
OpenAIRE
Journal :
Internal medicine (Tokyo, Japan)
Accession number :
edsair.doi.dedup.....b70e38cbb4a4b8f0ef544ff4886d7137