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Arterial and venous thrombosis in coronavirus 2019 disease (Covid-19):relationship with mortality

Arterial and venous thrombosis in coronavirus 2019 disease (Covid-19):relationship with mortality

Authors :
Violi, F.
Ceccarelli, G.
Cangemi, R.
Cipollone, F.
D'Ardes, D.
Oliva, A.
Pirro, M.
Rocco, M.
Alessandri, F.
D'Ettorre, G.
Lichtner, M.
Pignatelli, P.
Ferro, D.
Ruberto, F.
Lip, G. Y. H.
Pugliese, F.
Mastroianni, C. M.
Albante, A.
Auricchio, D.
De Lazzaro, F.
M. De Lauri D.
Di Santo, C.
Ianni, S.
Magnanimi, E.
Ratini, F.
Sabani, A.
Titi, L.
Vaccaro, P.
Giordano, G.
Manganelli, C.
Mancone, M.
Bruno, K.
Celli, P.
Consolo, S.
Croce, C.
Giannetti, L.
Martelli, S.
Messina, T.
Pattelli, E.
Perrella, S.
Portieri, M.
Ricci, C.
Almenrader, N.
Arzilla, R.
Delia, E.
Di Giovanni, C.
Laderchi, A.
Macri, C.
Marandola, M.
Nardecchia, G.
Pacilli, M.
Pacini, F.
Araimo Morselli, F.
Imperiale, C.
Tordiglione, P.
Ciardi, M. R.
Ajassa, C.
D'Agostino, C.
Russo, G.
Trinchieri, V.
Guariglia, P.
Antonelli, L.
Cuomo, R. M.
Carnevalini, M.
Mastropietro, C.
Iaiani, G.
Mezzaroma, I.
Falciano, M.
Brogi, A.
Celani, L.
Cavallari, N. E.
Rivano Capparuccia, M.
Massetti, A. P.
Fimiani, C.
Santori, M.
Bianchi, A.
Franchi, C.
De Angelis, M.
Sereno, S.
Furlan, C.
De Sanctis, G.
Paoletti, F.
Pasculli, P.
Cogliati Dezza, F.
Vassalini, P.
Cancelli, F.
De Girolamo, G.
Savelloni, G.
Valeri, S.
Siccardi, G.
Alessi, F.
Recchia, G.
Ridolfi, M.
Romani, F. E.
Aronica, R.
Filippi, V.
Vera, M.
Volpicelli, L.
Candy, M.
Alban, R.
Di Bari, S.
Gavaruzzi, F.
Casali, E.
Carli, M. S.
Zingaropoli, A. M.
Perri, V.
Santinelli, L.
Pinacchio, C.
Nijhawan, P.
Miele, C. M.
Innocenti, P. G.
Mengoni, F.
Source :
Violi, F, Ceccarelli, G, Cangemi, R, Cipollone, F, D'Ardes, D, Oliva, A, Pirro, M, Rocco, M, Alessandri, F, D'Ettorre, G, Lichtner, M, Pignatelli, P, Ferro, D, Ruberto, F, Lip, G Y H, Pugliese, F, Mastroianni, C M & Intensive Care, Infectious Diseases COVID-19 Study Group of Sapienza University 2021, ' Arterial and venous thrombosis in coronavirus 2019 disease (Covid-19) : relationship with mortality ', Internal and Emergency Medicine, vol. 16, no. 5, pp. 1231-1237 . https://doi.org/10.1007/s11739-020-02621-8, Internal and Emergency Medicine
Publication Year :
2021

Abstract

Background Patients with coronavirus disease 2019 (Covid-19) may experience venous thrombosis while data regarding arterial thrombosis are sparse. Methods Prospective multicenter study in 5 hospitals including 373 patients with Covid-19-related pneumonia. Demographic data, laboratory findings including coagulation tests and comorbidities were reported. During the follow-up any arterial or venous thrombotic events and death were registered. Results Among 373 patients, 75 (20%) had a thrombotic event and 75 (20%) died. Thrombotic events included 41 venous thromboembolism and 34 arterial thrombosis. Age, cardiovascular disease, intensive care unit treatment, white blood cells, D-dimer, albumin and troponin blood levels were associated with thrombotic events. In a multivariable regression logistic model, intensive care unit treatment (Odds Ratio [OR]: 6.0; 95% Confidence Interval [CI] 2.8–12.6; p p = 0.022); and albumin levels (OR: 0.49; 95% CI 0.28–0.87; p = 0.014) were associated with ischemic events. Age, sex, chronic obstructive pulmonary disease, diabetes, heart failure, coronary heart disease, intensive care unit treatment, in-hospital thrombotic events, D-dimer, C-reactive protein, troponin, and albumin levels were associated with mortality. A multivariable Cox regression analysis showed that in-hospital thrombotic events (hazard ratio [HR]: 2.72; 95% CI 1.59–4.65; p p = 0.001), and albumin (HR: 0.447; 95% CI 0.277–0.723; p = 0.001) predicted morality. Conclusions Covid-19 patients experience an equipollent rate of venous and arterial thrombotic events, that are associated with poor survival. Early identification and appropriate treatment of Covid-19 patients at risk of thrombosis may improve prognosis.

Details

Language :
English
Database :
OpenAIRE
Journal :
Violi, F, Ceccarelli, G, Cangemi, R, Cipollone, F, D'Ardes, D, Oliva, A, Pirro, M, Rocco, M, Alessandri, F, D'Ettorre, G, Lichtner, M, Pignatelli, P, Ferro, D, Ruberto, F, Lip, G Y H, Pugliese, F, Mastroianni, C M & Intensive Care, Infectious Diseases COVID-19 Study Group of Sapienza University 2021, ' Arterial and venous thrombosis in coronavirus 2019 disease (Covid-19) : relationship with mortality ', Internal and Emergency Medicine, vol. 16, no. 5, pp. 1231-1237 . https://doi.org/10.1007/s11739-020-02621-8, Internal and Emergency Medicine
Accession number :
edsair.doi.dedup.....b7160baec7c2ba231f87c0c97c531a16
Full Text :
https://doi.org/10.1007/s11739-020-02621-8