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Arterial and venous thrombosis in coronavirus 2019 disease (Covid-19):relationship with mortality
Arterial and venous thrombosis in coronavirus 2019 disease (Covid-19):relationship with mortality
- Source :
- Violi, F, Ceccarelli, G, Cangemi, R, Cipollone, F, D'Ardes, D, Oliva, A, Pirro, M, Rocco, M, Alessandri, F, D'Ettorre, G, Lichtner, M, Pignatelli, P, Ferro, D, Ruberto, F, Lip, G Y H, Pugliese, F, Mastroianni, C M & Intensive Care, Infectious Diseases COVID-19 Study Group of Sapienza University 2021, ' Arterial and venous thrombosis in coronavirus 2019 disease (Covid-19) : relationship with mortality ', Internal and Emergency Medicine, vol. 16, no. 5, pp. 1231-1237 . https://doi.org/10.1007/s11739-020-02621-8, Internal and Emergency Medicine
- Publication Year :
- 2021
-
Abstract
- Background Patients with coronavirus disease 2019 (Covid-19) may experience venous thrombosis while data regarding arterial thrombosis are sparse. Methods Prospective multicenter study in 5 hospitals including 373 patients with Covid-19-related pneumonia. Demographic data, laboratory findings including coagulation tests and comorbidities were reported. During the follow-up any arterial or venous thrombotic events and death were registered. Results Among 373 patients, 75 (20%) had a thrombotic event and 75 (20%) died. Thrombotic events included 41 venous thromboembolism and 34 arterial thrombosis. Age, cardiovascular disease, intensive care unit treatment, white blood cells, D-dimer, albumin and troponin blood levels were associated with thrombotic events. In a multivariable regression logistic model, intensive care unit treatment (Odds Ratio [OR]: 6.0; 95% Confidence Interval [CI] 2.8–12.6; p p = 0.022); and albumin levels (OR: 0.49; 95% CI 0.28–0.87; p = 0.014) were associated with ischemic events. Age, sex, chronic obstructive pulmonary disease, diabetes, heart failure, coronary heart disease, intensive care unit treatment, in-hospital thrombotic events, D-dimer, C-reactive protein, troponin, and albumin levels were associated with mortality. A multivariable Cox regression analysis showed that in-hospital thrombotic events (hazard ratio [HR]: 2.72; 95% CI 1.59–4.65; p p = 0.001), and albumin (HR: 0.447; 95% CI 0.277–0.723; p = 0.001) predicted morality. Conclusions Covid-19 patients experience an equipollent rate of venous and arterial thrombotic events, that are associated with poor survival. Early identification and appropriate treatment of Covid-19 patients at risk of thrombosis may improve prognosis.
- Subjects :
- Male
covid-19
mortality
sars-cov-2
thrombosis
Coronary Artery Disease
Kaplan-Meier Estimate
030204 cardiovascular system & hematology
law.invention
Coronary artery disease
0302 clinical medicine
law
80 and over
Coronary Artery Disease/epidemiology
Odds Ratio
SARS-cov-2
030212 general & internal medicine
Prospective Studies
Aged, 80 and over
Thromboembolism/epidemiology
biology
Hazard ratio
Middle Aged
Mortality/trends
Intensive care unit
Thrombosis
Venous thrombosis
Intensive Care Units
C-Reactive Protein
Emergency Medicine
Cardiology
COVID-19/complications
Female
medicine.medical_specialty
Fibrin Fibrinogen Degradation Products/analysis
Fibrin Fibrinogen Degradation Products
03 medical and health sciences
C-Reactive Protein/analysis
Internal medicine
Thromboembolism
Internal Medicine
medicine
Humans
Mortality
Aged
Proportional Hazards Models
Intensive Care Units/organization & administration
business.industry
C-reactive protein
COVID-19
Odds ratio
medicine.disease
Im - Original
Logistic Models
Heart failure
biology.protein
business
Subjects
Details
- Language :
- English
- Database :
- OpenAIRE
- Journal :
- Violi, F, Ceccarelli, G, Cangemi, R, Cipollone, F, D'Ardes, D, Oliva, A, Pirro, M, Rocco, M, Alessandri, F, D'Ettorre, G, Lichtner, M, Pignatelli, P, Ferro, D, Ruberto, F, Lip, G Y H, Pugliese, F, Mastroianni, C M & Intensive Care, Infectious Diseases COVID-19 Study Group of Sapienza University 2021, ' Arterial and venous thrombosis in coronavirus 2019 disease (Covid-19) : relationship with mortality ', Internal and Emergency Medicine, vol. 16, no. 5, pp. 1231-1237 . https://doi.org/10.1007/s11739-020-02621-8, Internal and Emergency Medicine
- Accession number :
- edsair.doi.dedup.....b7160baec7c2ba231f87c0c97c531a16
- Full Text :
- https://doi.org/10.1007/s11739-020-02621-8