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Peripheral blood mononuclear cells in the squirrel monkey Saimiri sciureus. II. Exploration of the IL2/IL2R pathway of T-cell activation
- Source :
- Research in immunology. 142(9)
- Publication Year :
- 1991
-
Abstract
- We report here on functional aspects of squirrel monkey T cells isolated either from peripheral blood mononuclear cells or in the presence of accessory cells or accessory-cell-secreted cytokines. The T-cell response triggered by polyclonal activators was measured through proliferation, T-cell growth factor production and transient expression of receptors to growth factors. We also sought to delineate mechanisms by which antimitogenic molecules might prevent lymphocytes from being able to express "activation antigens" and/or from proliferating. Under these conditions, we mainly explored the inducible IL2/IL2R pathway and phenomena occurring in lymphocyte "non-activation" in terms of early and late cellular events; indeed, defects in the IL2/IL2R pathway represent one of the dysregulation events presumed to occur during the acute phase of human malaria, disease for which. Saimiri monkeys have been selected as experimental hosts.
- Subjects :
- Interleukin 2
Male
Lymphocyte
medicine.medical_treatment
T cell
T-Lymphocytes
Immunology
Lymphocyte Activation
Peripheral blood mononuclear cell
Receptors, Transferrin
medicine
Animals
Phytohemagglutinins
Saimiri
Cells, Cultured
biology
Growth factor
Squirrel monkey
Saimiri sciureus
Antibodies, Monoclonal
Receptors, Interleukin-2
biology.organism_classification
Receptor, Insulin
Cell biology
Malaria
Disease Models, Animal
medicine.anatomical_structure
Cytokine
Leukocytes, Mononuclear
Interleukin-2
Female
Mitogens
medicine.drug
Subjects
Details
- ISSN :
- 09232494
- Volume :
- 142
- Issue :
- 9
- Database :
- OpenAIRE
- Journal :
- Research in immunology
- Accession number :
- edsair.doi.dedup.....b72bc6b6b4c2693525914400129dd89d