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Tenofovir versus tenofovir plus entecavir for chronic hepatitis B with lamivudine resistance and entecavir resistance
- Source :
- Journal of Viral Hepatitis. 24:141-147
- Publication Year :
- 2016
- Publisher :
- Wiley, 2016.
-
Abstract
- Summary We compared the viral suppressive efficacy of tenofovir disoproxil fumarate (TDF) mono-rescue therapy (TDF group) and TDF plus entecavir (ETV) combination-rescue therapy (TDF + ETV group) in chronic hepatitis B (CHB) patients with lamivudine resistance and entecavir resistance. One hundred and thirty-three CHB patients with lamivudine and entecavir resistance were investigated. Ninety-six patients were treated with TDF and 37 with TDF + ETV for at least 6 months. We compared the virologic response rate (HBV DNA level
- Subjects :
- Adult
Male
0301 basic medicine
Hepatitis B virus
medicine.medical_specialty
Guanine
Tenofovir
Antiviral Agents
Gastroenterology
Young Adult
03 medical and health sciences
Hepatitis B, Chronic
0302 clinical medicine
Chronic hepatitis
Virology
Internal medicine
Drug Resistance, Viral
Combination strategy
Humans
Medicine
Aged
Aged, 80 and over
Hepatology
business.industry
Lamivudine
Entecavir
Middle Aged
Viral Load
Lamivudine resistance
Multiple drug resistance
Treatment Outcome
030104 developmental biology
Infectious Diseases
Virologic response
DNA, Viral
Female
030211 gastroenterology & hepatology
business
medicine.drug
Subjects
Details
- ISSN :
- 13520504
- Volume :
- 24
- Database :
- OpenAIRE
- Journal :
- Journal of Viral Hepatitis
- Accession number :
- edsair.doi.dedup.....b7549e55786f54b70836e60d5a3db26e
- Full Text :
- https://doi.org/10.1111/jvh.12623