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Expression of breast cancer resistance protein in peripheral T cell subsets from HIV‑1‑infected patients with antiretroviral therapy
- Source :
- Molecular medicine reports. 10(2)
- Publication Year :
- 2013
-
Abstract
- The aim of the present study was to investigate the expression of breast cancer resistance protein (BCRP) in peripheral T cell subsets of human immunodeficiency virus 1 (HIV‑1)‑infected patients, and to analyze the association between the levels of BCRP expression and disease progression in HIV‑1 infection. Peripheral blood mononuclear cells (PBMCs) were obtained from HIV‑1‑infected patients (n=118), including 92 patients with antiretroviral therapy (ART) and 26 patients without a history of ART. Control samples from 30 healthy donors were also analyzed. The expression levels of BCRP in T cells were evaluated by flow cytometry. A high inter‑individual variability was observed in CD4+ and CD8+ T cells in the HIV‑1‑infected patients and healthy donors; however, the analyzed expression levels of BCRP were significantly higher in the HIV‑1‑infected group with ART than those in the group with no history of ART (P
- Subjects :
- Oncology
Adult
CD4-Positive T-Lymphocytes
Male
Cancer Research
medicine.medical_specialty
T cell
HIV Infections
Drug resistance
Biology
CD8-Positive T-Lymphocytes
medicine.disease_cause
Biochemistry
Peripheral blood mononuclear cell
Internal medicine
Antiretroviral Therapy, Highly Active
Genetics
medicine
ATP Binding Cassette Transporter, Subfamily G, Member 2
Humans
RNA, Messenger
Molecular Biology
Oncogene
Cancer
Middle Aged
Viral Load
medicine.disease
Molecular medicine
Neoplasm Proteins
medicine.anatomical_structure
Immunology
HIV-1
Leukocytes, Mononuclear
Molecular Medicine
Reverse Transcriptase Inhibitors
ATP-Binding Cassette Transporters
Female
Carcinogenesis
CD8
Subjects
Details
- ISSN :
- 17913004
- Volume :
- 10
- Issue :
- 2
- Database :
- OpenAIRE
- Journal :
- Molecular medicine reports
- Accession number :
- edsair.doi.dedup.....b760fa9a5bf002055c99c6dfc2764224