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Plasma zinc alpha2-glycoprotein levels correlate positively with frailty severity in female elders
- Source :
- Medicine
- Publication Year :
- 2016
- Publisher :
- Wolters Kluwer Health, 2016.
-
Abstract
- Frailty is a geriatric syndrome associated with adiposity. Zinc alpha2-glycoprotein (ZAG), a novel adipokine, is a modulator of body fat mass and positively correlates with age. This observational study aims to investigate the relationship between plasma ZAG levels and frailty in the elderly. We enrolled 189 elder participants from a hospital-based comprehensive geriatric assessment program in Taiwan from January 2007 to June 2008. The demographic data, body weight, body mass index, appendicular skeletal muscle mass index (ASMI), body fat mass percentage, metabolic and inflammatory parameters including plasma tumor-necrosis factor alpha, C-reactive protein and ZAG levels, were assessed. The frailty score was assessed by Fried Frailty Index. The mean age of all participants (91 [48.1%] men and 98 [51.9%] women) was 77.19 ± 6.12 years. Judged by the FFI score, 46 (24.34%) elders were robust, 106 (56.08%) were pre-frail, and 37 (19.58%) were frail. Older men showed greater ASMI and lower fat mass percentage in comparison to older women (P
- Subjects :
- 0301 basic medicine
Male
medicine.medical_specialty
Frail Elderly
Alpha (ethology)
Adipokine
Observational Study
030209 endocrinology & metabolism
frailty
Body weight
Demographic data
Zn-Alpha-2-Glycoprotein
Gastroenterology
Body Mass Index
03 medical and health sciences
0302 clinical medicine
Sex Factors
Internal medicine
Medicine
Body Fat Distribution
Humans
Muscle, Skeletal
Geriatric Assessment
Plasma zinc
Aged
Aged, 80 and over
elders
business.industry
Body Weight
Seminal Plasma Proteins
Geriatric assessment
General Medicine
030104 developmental biology
Endocrinology
Cytokines
Multiple linear regression analysis
Female
business
Body mass index
Research Article
zinc alpha2-glycoprotein
Subjects
Details
- Language :
- English
- ISSN :
- 15365964 and 00257974
- Volume :
- 95
- Issue :
- 35
- Database :
- OpenAIRE
- Journal :
- Medicine
- Accession number :
- edsair.doi.dedup.....b76888d5d9ef2553d0dedb8750eb24b7