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Urinary oestrogen steroidome as an indicator of the risk of localised prostate cancer progression

Authors :
Éric Lévesque
Fred Saad
Michel Carmel
Jean-Philippe Emond
Armen Aprikian
Véronique Turcotte
Patrick Caron
David Simonyan
Chantal Guillemette
Louis Lacombe
Simone Chevalier
Source :
Br J Cancer
Publication Year :
2021

Abstract

Background Prostate cancer (PCa) is the most common cancer in North American men. Beyond the established contribution of androgens to disease progression, growing evidence suggest that oestrogen-related pathways might also be of clinical importance. The aim of this study was to explore the association of urinary oestrogen levels with clinical outcomes. Methods Urine samples from the prospective multi-institutional PROCURE cohort were collected before RP for discovery (n = 259) and validation (n = 253). Urinary total oestrogens (unconjugated + conjugated), including oestrone and oestradiol, their bioactive and inactive catechol and methyl derivatives (n = 15), were measured using mass spectrometry (MS). Results The median follow-up time for the discovery and replication cohorts was 7.6 and 6.5 years, respectively. Highly significant correlations between urinary oestrogens were observed; however, correlations with circulating oestrogens were modest. Our findings indicate that higher levels of urinary oestriol and 16-ketoestradiol were associated with lower risk of BCR. In contrast, higher levels of 2-methoxyestrone were associated with an increased risk of development of metastasis/deaths. Conclusions Our data suggest that urinary levels of oestriol and 16-ketoestradiol metabolites are associated with a more favourable outcome, whereas those of 2-methoxyestrone are associated with an elevated risk of metastasis after RP. Further studies are required to better understand the impact of oestrogens on disease biology and as easily accessible urine-based risk-stratification markers.

Details

ISSN :
15321827
Volume :
125
Issue :
1
Database :
OpenAIRE
Journal :
British journal of cancer
Accession number :
edsair.doi.dedup.....b76d5a1b8c0fe03fc18805db89fe974f