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Urinary oestrogen steroidome as an indicator of the risk of localised prostate cancer progression
- Source :
- Br J Cancer
- Publication Year :
- 2021
-
Abstract
- Background Prostate cancer (PCa) is the most common cancer in North American men. Beyond the established contribution of androgens to disease progression, growing evidence suggest that oestrogen-related pathways might also be of clinical importance. The aim of this study was to explore the association of urinary oestrogen levels with clinical outcomes. Methods Urine samples from the prospective multi-institutional PROCURE cohort were collected before RP for discovery (n = 259) and validation (n = 253). Urinary total oestrogens (unconjugated + conjugated), including oestrone and oestradiol, their bioactive and inactive catechol and methyl derivatives (n = 15), were measured using mass spectrometry (MS). Results The median follow-up time for the discovery and replication cohorts was 7.6 and 6.5 years, respectively. Highly significant correlations between urinary oestrogens were observed; however, correlations with circulating oestrogens were modest. Our findings indicate that higher levels of urinary oestriol and 16-ketoestradiol were associated with lower risk of BCR. In contrast, higher levels of 2-methoxyestrone were associated with an increased risk of development of metastasis/deaths. Conclusions Our data suggest that urinary levels of oestriol and 16-ketoestradiol metabolites are associated with a more favourable outcome, whereas those of 2-methoxyestrone are associated with an elevated risk of metastasis after RP. Further studies are required to better understand the impact of oestrogens on disease biology and as easily accessible urine-based risk-stratification markers.
- Subjects :
- Male
Cancer Research
Hydroxyestrones
Urinary system
Physiology
Disease
Urine
Lower risk
Mass Spectrometry
Article
Metastasis
03 medical and health sciences
Prostate cancer
0302 clinical medicine
Medicine
Humans
Prospective Studies
Aged
Estradiol
business.industry
Cancer
Prostatic Neoplasms
Middle Aged
medicine.disease
Oncology
030220 oncology & carcinogenesis
Cohort
Disease Progression
business
Subjects
Details
- ISSN :
- 15321827
- Volume :
- 125
- Issue :
- 1
- Database :
- OpenAIRE
- Journal :
- British journal of cancer
- Accession number :
- edsair.doi.dedup.....b76d5a1b8c0fe03fc18805db89fe974f