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Progress in targeting bacterial transcription
- Source :
- Drug Discovery Today, Drug Discovery Today, Elsevier, 2007, 12 (5-6), pp.200-8. ⟨10.1016/j.drudis.2007.01.005⟩
- Publication Year :
- 2007
- Publisher :
- Elsevier BV, 2007.
-
Abstract
- The bacterial RNA polymerase (RNAP) is an essential enzyme that is responsible for making RNA from a DNA template and is targeted by several antibiotics. Rifampicin was the first of such antibiotics to be described and is one of the most efficient anti-tuberculosis drugs in use. In the past five years, structural studies of bacterial RNAP and the resolution of several complexes of drugs bound to RNAP subunits have revealed molecular details of the drug-binding sites and the mechanism of drug action. This knowledge opens avenues for the development of antibiotics. Here these drugs are reviewed, together with their mechanisms and their potential interest for therapeutic applications.
- Subjects :
- Transcription, Genetic
MESH: Drug Delivery Systems
[SDV.BC]Life Sciences [q-bio]/Cellular Biology
Drug action
MESH: Drug Design
Structure-Activity Relationship
03 medical and health sciences
MESH: Structure-Activity Relationship
Drug Delivery Systems
Transcription (biology)
Bacterial transcription
MESH: Anti-Bacterial Agents
Drug Discovery
medicine
Humans
Binding site
Antibiotics, Antitubercular
MESH: Antibiotics, Antitubercular
Polymerase
030304 developmental biology
Antibacterial agent
Pharmacology
0303 health sciences
MESH: Humans
Binding Sites
biology
030306 microbiology
MESH: Transcription, Genetic
RNA
DNA-Directed RNA Polymerases
MESH: Protein Subunits
MESH: Rifampin
MESH: DNA-Directed RNA Polymerases
Anti-Bacterial Agents
3. Good health
Protein Subunits
RNA, Bacterial
MESH: Binding Sites
Mechanism of action
Biochemistry
Drug Design
biology.protein
Rifampin
medicine.symptom
MESH: RNA, Bacterial
Subjects
Details
- ISSN :
- 13596446
- Volume :
- 12
- Database :
- OpenAIRE
- Journal :
- Drug Discovery Today
- Accession number :
- edsair.doi.dedup.....b7776f7179c86f8c23dcf9a816357cdb