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Clonidine, an α2 adrenergic receptor agonist, disrupts reconsolidation of a cocaine-paired environmental memory
- Source :
- Behavioural Pharmacology
- Publication Year :
- 2019
- Publisher :
- Ovid Technologies (Wolters Kluwer Health), 2019.
-
Abstract
- Environmental cues can elicit robust cocaine reward memories, contributing to relapse to cocaine abuse. Memories can be manipulated pharmacologically by interfering with reconsolidation after reactivation. Clonidine, an α2 noradrenergic receptor agonist, was tested for its ability to block reconsolidation of cocaine environmental-paired memory. Male Sprague-Dawley rats completed an 8-day cocaine place conditioning procedure to establish a cocaine place preference. Cocaine memory was reactivated by exposure to the cocaine-paired environment in a drug-free state, followed immediately by administration of clonidine (10 or 50 µg/kg) or vehicle. Cocaine place preference was retested 24 h and 1 week later. Clonidine significantly attenuated the previously established cocaine place preference when tested 1 or 7 days later. To investigate the generalizability of this effect to other drug classes, morphine conditioned place preference was tested. Clonidine administration after morphine memory reactivation did not significantly alter the expression of morphine place preference. These results suggest that clonidine can interfere with reconsolidation of cocaine memory and may be a useful approach to reduce relapse.
- Subjects :
- Male
Agonist
medicine.drug_class
Conditioning, Classical
Adrenergic
Pharmacology
Clonidine
norepinephrine
Rats, Sprague-Dawley
Cocaine-Related Disorders
03 medical and health sciences
0302 clinical medicine
Cocaine
Reward
Short Reports
Memory
Receptors, Adrenergic, alpha-2
Adrenergic alpha-2 Receptor Agonists
Animals
Medicine
rat
Receptor
Memory Consolidation
α2 adrenergic receptor
business.industry
morphine
Adrenergic Agonists
conditioned place preference
Conditioned place preference
Rats
030227 psychiatry
Psychiatry and Mental health
Morphine
Memory consolidation
Cues
adrenergic receptors
business
030217 neurology & neurosurgery
medicine.drug
Subjects
Details
- ISSN :
- 09558810
- Volume :
- 30
- Database :
- OpenAIRE
- Journal :
- Behavioural Pharmacology
- Accession number :
- edsair.doi.dedup.....b7beb8fe4716dbbc54c1d1c664f0de90
- Full Text :
- https://doi.org/10.1097/fbp.0000000000000473