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Concurrent OCT and OCT angiography of retinal neurovascular degeneration in the 5XFAD Alzheimer’s disease mice
- Source :
- Neurophotonics
- Publication Year :
- 2021
- Publisher :
- SPIE-Intl Soc Optical Eng, 2021.
-
Abstract
- Significance: As one part of the central nervous system, the retina manifests neurovascular defects in Alzheimer’s disease (AD). Quantitative imaging of retinal neurovascular abnormalities may promise a new method for early diagnosis and treatment assessment of AD. Previous imaging studies of transgenic AD mouse models have been limited to the central part of the retina. Given that the pathological hallmarks of AD frequently appear in different peripheral quadrants, a comprehensive regional investigation is needed for a better understanding of the retinal degeneration associated with AD-like pathology. Aim: We aim to demonstrate concurrent optical coherence tomography (OCT) and OCT angiography (OCTA) of retinal neuronal and vascular abnormalities in the 5XFAD mouse model and to investigate region-specific retinal degeneration. Approach: A custom-built OCT system was used for retinal imaging. Retinal thickness, vessel width, and vessel density were quantitatively measured. The artery and vein (AV) were classified for differential AV analysis, and trilaminar vascular plexuses were segmented for depth-resolved density measurement. Results: It was observed that inner and outer retinal thicknesses were explicitly reduced in the dorsal and temporal quadrants, respectively, in 5XFAD mice. A significant arterial narrowing in 5XFAD mice was also observed. Moreover, overall capillary density consistently showed a decreasing trend in 5XFAD mice, but regional specificity was not identified. Conclusions: Quadrant- and layer-specific neurovascular degeneration was observed in 5XFAD mice. Concurrent OCT and OCTA promise a noninvasive method for quantitative monitoring of AD progression and treatment assessment.
- Subjects :
- Paper
Retinal degeneration
retina
Pathology
medicine.medical_specialty
Central nervous system
Neuroscience (miscellaneous)
chemistry.chemical_compound
Optical coherence tomography
medicine
Radiology, Nuclear Medicine and imaging
5XFAD
Retina
Radiological and Ultrasound Technology
medicine.diagnostic_test
business.industry
Retinal
neurovascular degeneration
medicine.disease
Neurovascular bundle
Research Papers
medicine.anatomical_structure
OCT
chemistry
Angiography
sense organs
OCTA
business
Alzheimer’s disease
Artery
Subjects
Details
- ISSN :
- 2329423X
- Volume :
- 8
- Database :
- OpenAIRE
- Journal :
- Neurophotonics
- Accession number :
- edsair.doi.dedup.....b7fa54cc2ea081600a3c77bcf7b2c5d7