Back to Search
Start Over
Lupus-like autoimmunity and increased interferon response in patients with STAT3-deficient hyper-IgE syndrome
- Source :
- J Allergy Clin Immunol
- Publication Year :
- 2021
- Publisher :
- Elsevier BV, 2021.
-
Abstract
- We report on patients with STAT3 loss-of-function (LOF) mutations who developed lupus-like autoimmunity. Immune dysregulation seen in STAT3 LOF patients suggests a susceptibility to systemic autoimmunity with important implications in monitoring and management of these patients.
- Subjects :
- Male
STAT3 Transcription Factor
Adolescent
Immunology
medicine.disease_cause
Immunoglobulin E
Article
Autoimmune Diseases
Autoimmunity
Young Adult
Loss of Function Mutation
Interferon
medicine
Humans
Lupus Erythematosus, Systemic
Immunology and Allergy
Young adult
Child
STAT3
Retrospective Studies
Systemic lupus erythematosus
Lupus erythematosus
biology
business.industry
Immune dysregulation
medicine.disease
Interferon Type I
biology.protein
Female
business
Job Syndrome
medicine.drug
Subjects
Details
- ISSN :
- 00916749
- Volume :
- 147
- Database :
- OpenAIRE
- Journal :
- Journal of Allergy and Clinical Immunology
- Accession number :
- edsair.doi.dedup.....b7fe5cd9667882d00aa4f2f8a6493f50
- Full Text :
- https://doi.org/10.1016/j.jaci.2020.07.024