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Continuous flow left ventricular assist devices do not worsen endothelial function in subjects with chronic heart failure: a pilot study
- Source :
- ESC Heart Failure, ESC Heart Failure, Vol 8, Iss 5, Pp 3587-3593 (2021)
- Publication Year :
- 2021
- Publisher :
- John Wiley and Sons Inc., 2021.
-
Abstract
- Aims: To evaluate endothelial function in subjects with left ventricular assist devices (LVADs), comparing them with subjects with chronic heart failure with reduced ejection fraction on the list for heart transplant (HT) and with HT patients with a normal systolic cardiac function to identify any differences. Methods: We enrolled 28 subjects with LVAD, 55 subjects with HT, and 42 subjects with heart failure on the transplant list. The subjects underwent a general physical examination, assessment of laboratory blood parameters, and assessment of endothelial function through flow-mediated dilation (FMD) of brachial artery. Results: The three groups were homogeneous as regards age, gender, smoke abuse, C-reactive protein (CRP) and FMD parameters (P=ns). In LVAD group percentage of FMD change showed an inverse correlation with CRP (rho: −0.5, P: 0.003), a well-known marker of inflammation and tissue damage. Conclusions: Continuous flow related to LVAD seems to not worsen endothelial function. Endothelial function was not affected by cardiovascular risk factors (hypertension, hypercholesterolaemia, diabetes, obesity, and tobacco habit), by the functional status expressed by New York Heart Association class, by the left ventricular systolic function and by the presence or absence of ischaemic heart disease in all the populations analysed. CRP was the only factor able to influence percentage of FMD change in patient with LVAD, reinforcing the hypothesis that inflammation is the main determinant of endothelial function.
- Subjects :
- Cardiac function curve
medicine.medical_specialty
New York Heart Association Class
Inflammation
Pilot Projects
Ventricular Function, Left
medicine.artery
Internal medicine
Diabetes mellitus
Original Research Articles
medicine
Continuous flow left ventricular assist device
Diseases of the circulatory (Cardiovascular) system
Humans
Original Research Article
Brachial artery
Heart Failure
Ejection fraction
business.industry
Endothelial function
medicine.disease
Obesity
Heart failure
RC666-701
Cardiology
Heart Transplantation
Heart transplant
Heart-Assist Devices
medicine.symptom
Cardiology and Cardiovascular Medicine
business
Subjects
Details
- Language :
- English
- ISSN :
- 20555822
- Volume :
- 8
- Issue :
- 5
- Database :
- OpenAIRE
- Journal :
- ESC Heart Failure
- Accession number :
- edsair.doi.dedup.....b8042024374f782df2257283e48dc5fa