Antibodies to Z DNA stabilized with polyarginine

Authors :: V. Adouard
Bernard Révet
Alain Niveleau
Robert Dante
Etienne Delain
Benoît Roux
Source :: FEBS Letters. 191:67-71
Publication Year :: 1985
Publisher :: Wiley, 1985.
Abstract: The left-handed form of poly (dG-m5dC).poly(dG-m5dC) induced by heating the copolymer in the presence of magnesium and stabilized with polyarginine can be used to raise antibodies in rabbits. These antibodies are able to recognize the Z conformation of both methylated and nonmethylated forms of the copolymers. In the same experimental conditions, hypermethylated B DNA is not recognized by these antibodies.