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Body Mass Index, Waist Circumference, Diabetes, and Risk of Liver Cancer for U.S. Adults
- Source :
- Cancer Research. 76:6076-6083
- Publication Year :
- 2016
- Publisher :
- American Association for Cancer Research (AACR), 2016.
-
Abstract
- Incidence rates for liver cancer have increased 3-fold since the mid-1970s in the United States in parallel with increasing trends for obesity and type II diabetes mellitus. We conducted an analysis of baseline body mass index (BMI), waist circumference (WC), and type II diabetes mellitus with risk of liver cancer. The Liver Cancer Pooling Project maintains harmonized data from 1.57 million adults enrolled in 14 U.S.-based prospective studies. Cox regression estimated HRs and 95% confidence intervals (CI) adjusted for age, sex, study center, alcohol, smoking, race, and BMI (for WC and type II diabetes mellitus). Stratified analyses assessed whether the BMI–liver cancer associations differed by hepatitis sera-positivity in nested analyses for a subset of cases (n = 220) and controls (n = 547). After enrollment, 2,162 incident liver cancer diagnoses were identified. BMI, per 5 kg/m2, was associated with higher risks of liver cancer, more so for men (HR = 1.38; 95% CI, 1.30–1.46) than women (HR = 1.25; 95% CI, 1.17–1.35; Pinteraction = 0.02). WC, per 5 cm, was associated with higher risks of liver cancer, approximately equally by sex (overall, HR = 1.08; 95% CI, 1.04–1.13). Type II diabetes mellitus was associated with higher risk of liver cancer (HR = 2.61; 95% CI, 2.34–2.91). In stratified analyses, there was a null association between BMI and liver cancer risk for participants who were sera-positive for hepatitis. This study suggests that high BMI, high WC, and type II diabetes mellitus are associated with higher risks of liver cancer and that the association may differ by status of viral hepatitis infection. Cancer Res; 76(20); 6076–83. ©2016 AACR.
- Subjects :
- Adult
Male
Cancer Research
medicine.medical_specialty
Waist
Article
Body Mass Index
03 medical and health sciences
0302 clinical medicine
Risk Factors
Internal medicine
Diabetes mellitus
medicine
Humans
Prospective Studies
Prospective cohort study
Aged
Proportional Hazards Models
Hepatitis
business.industry
Liver Neoplasms
nutritional and metabolic diseases
Cancer
Middle Aged
medicine.disease
Obesity
Endocrinology
Diabetes Mellitus, Type 2
Oncology
030220 oncology & carcinogenesis
Female
030211 gastroenterology & hepatology
Waist Circumference
Liver cancer
business
Body mass index
Subjects
Details
- ISSN :
- 15387445 and 00085472
- Volume :
- 76
- Database :
- OpenAIRE
- Journal :
- Cancer Research
- Accession number :
- edsair.doi.dedup.....b82004a3bfd13a7d53c1ee122d4fc2e5